-
Article
Open AccessUse of maximal dosage renin-angiotensin-aldosterone system inhibitors in a real life population of complicated type 2 diabetes – contraindications and opportunities
Pharmacological inhibition of the renin-angiotensin-aldosterone-system (RAASi) is the cornerstone of hypertension treatment, renoprotection and secondary prevention of cardiovascular disease in patients with t...
-
Article
Correction to: Sex differences in the association between plasma copeptin and incident type 2 diabetes: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study
The values given for copeptin levels in men in quartiles 1 and 2 (Table 1) were incorrect, and should have read.
-
Article
Open AccessTrajectories of metabolic risk factors and biochemical markers prior to the onset of type 2 diabetes: the population-based longitudinal Doetinchem study
Risk factors often develop at young age and are maintained over time, but it is not fully understood how risk factors develop over time preceding type 2 diabetes. We examined how levels and trajectories of met...
-
Article
Effects of sodium and potassium supplementation on blood pressure and arterial stiffness: a fully controlled dietary intervention study
We performed a randomised, placebo-controlled, crossover study to examine the effects of sodium and potassium supplementation on blood pressure (BP) and arterial stiffness in untreated (pre)hypertensive indivi...
-
Article
Sex specific association between carnosinase gene CNDP1 and cardiovascular mortality in patients with type 2 diabetes (ZODIAC-22)
Homozygosity for a 5-leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been associated with a reduced prevalence of diabetic nephropathy in cross-sectional studies in patients with type 2 diabetes, parti...
-
Article
Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss: the DiOGenes randomized study
Randomized trials have shown significant blood pressure (BP) reductions after increased protein compared with carbohydrate intake, but the effect on BP maintenance after initial weight loss is unclear. We exam...
-
Article
Intake of total protein, plant protein and animal protein in relation to blood pressure: a meta-analysis of observational and intervention studies
There is growing evidence from epidemiological studies that dietary protein may beneficially influence blood pressure (BP), but findings are inconclusive. We performed a meta-analysis of 29 observational studi...
-
Article
Copeptin, a surrogate marker for arginine vasopressin, is associated with declining glomerular filtration in patients with diabetes mellitus (ZODIAC-33)
Arginine vasopressin (AVP), the hormone important for maintaining fluid balance, has been shown to cause kidney damage in rodent models of diabetes. We investigated the potential role of AVP in the natural cou...
-
Article
A urinary peptide biomarker set predicts worsening of albuminuria in type 2 diabetes mellitus
Microalbuminuria is considered the first clinical sign of kidney dysfunction and is associated with a poor renal and cardiovascular prognosis in type 2 diabetes. Detection of patients who are prone to develop ...
-
Article
Sex differences in the association between plasma copeptin and incident type 2 diabetes: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study
Vasopressin plays a role in osmoregulation, glucose homeostasis and inflammation. Therefore, plasma copeptin, the stable C-terminal portion of the precursor of vasopressin, has strong potential as a biomarker ...
-
Article
Plasma procalcitonin and risk of type 2 diabetes in the general population
-
Article
Open AccessA polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus
Homozygosity for a five leucine repeat (5L–5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We pr...
-
Article
Open AccessVitamin D as an accelerator of atherosclerotic calcification: a D-tail that may be a Trojan horse
-
Article
Open AccessCopper chelation as a potential treatment for left-ventricular hypertrophy in type 2 diabetes
-
Article
Open AccessThiamine in diabetic nephropathy: a novel treatment modality?
-
Article
Open AccessOptimal dosing of renin–angiotensin–aldosterone system blockers for renal protection: a solved issue?
-
Article
35th Annual Meeting of the European Association for the Study of Diabetes
-
Article
The association of dietary fibres with glucose tolerance is partly explained by concomitant intake of thiamine: The Hoorn Study
Epidemiologic studies have shown an association between the intake of dietary fibres and 2-h glucose values. Food rich in dietary fibres is often also rich in thiamine. Animal studies have shown that thiamine...
