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  1. Article

    Open Access

    TNFR1-d2 carrying the p.(Thr79Met) pathogenic variant is a potential novel actor of TNFα/TNFR1 signalling regulation in the pathophysiology of TRAPS

    Binding of tumour necrosis factor α (TNFα) to its receptor (TNFR1) is critical for both survival and death cellular pathways. TNFα/TNFR1 signalling is complex and tightly regulated at different levels to contr...

    Cécile Rittore, Déborah Méchin, Elodie Sanchez, Léa Marinèche… in Scientific Reports (2021)

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    Quantitative Analysis of Intra-chromosomal Contacts: The 3C-qPCR Method

    The chromosome conformation capture (3C) technique is fundamental to many population-based methods investigating chromatin dynamics and organization in eukaryotes. Here, we provide a modified quantitative 3C (...

    Vuthy Ea, Franck Court, Thierry Forné in Population Epigenetics (2017)

  3. Article

    Open Access

    Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains

    In higher eukaryotes, the genome is partitioned into large "Topologically Associating Domains" (TADs) in which the chromatin displays favoured long-range contacts. While a crumpled/fractal globule organization...

    Vuthy Ea, Tom Sexton, Thierry Gostan, Laurie Herviou, Marie-Odile Baudement… in BMC Genomics (2015)

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