15 Result(s)

Article

Video-Based Kinematic Analysis of Movement Quality in a Phase 3 Clinical Trial of Troriluzole in Adults with Spinocerebellar Ataxia: A Post Hoc Analysis

Traditional methods for assessing movement quality rely on subjective standardized scales and clinical expertise. This limitation creates challenges for assessing patients with spinocerebellar ataxia (SCA), in...

Gilbert J. L’Italien, Evangelos K. Oikonomou, Rohan Khera… in Neurology and Therapy (2024)

Article

Ataxia Rating Scales Reflect Patient Experience: an Examination of the Relationship Between Clinician Assessments of Cerebellar Ataxia and Patient-Reported Outcomes

Ataxia rating scales are observer administered clinical outcome assessments (COAs) of the cerebellar motor syndrome. It is not known whether these COAs mirror patient experience of their disease. Here we test ...

Michele H. Potashman, Miranda L. Mize, Melissa W. Beiner, Samantha Pierce… in The Cerebellum (2023)

Article

Observational Analysis of the Costs Associated with Acute Treatment of Breakthrough Migraine Attacks in Medicaid Patients Using Preventive Therapies

Medications for preventive treatment of migraine reduce migraine frequency, usually measured by a reduction in monthly migraine days (MMD), but generally do not eliminate the need for acute treatment. To asses...

Linda Harris, Tom O’Connell, Jonathan J. Woolley, Gilbert L’Italien… in Advances in Therapy (2023)

Article

Health State Utility Map** of Rimegepant for the Preventive Treatment of Migraine: Double-Blind Treatment Phase and Open Label Extension (BHV3000-305)

The objectives of this study were to (1) report long-term health-related quality of life (HRQoL) outcomes among patients using rimegepant preventatively in BHV3000-305 (NCT03732638) open-label extension (OLE) ...

Lauren C. Powell, Gilbert L’Italien, Evan Popoff, Karissa Johnston… in Advances in Therapy (2023)

Article

Measuring interictal burden among people affected by migraine: a descriptive survey study

Previous research has extensively documented the impact of migraine episodes (‘ictal’) on patients’ health-related quality of life. Few studies have looked at the impact of migraine on migraine-free days (‘int...

Lena T. Hubig, Timothy Smith, Emma Williams… in The Journal of Headache and Pain (2022)

Article

Real-World experience of interictal burden and treatment in migraine: a qualitative interview study

The debilitating nature of migraine attacks is widely established; however, less is known about how the interictal burden (i.e., how patients are affected in-between migraine episodes) of migraine impacts on p...

Siu Hing Lo, Katy Gallop, Timothy Smith, Lauren Powell… in The Journal of Headache and Pain (2022)

Article

Monthly migraine days, tablet utilization, and quality of life associated with Rimegepant – post hoc results from an open label safety study (BHV3000–201)

The objective of this study was to describe patterns in monthly migraine days (MMD) and tablet utilization, and to estimate health-related quality of life (HRQoL) measures in patients treated as needed (PRN) w...

Karissa Johnston, Linda Harris, Lauren Powell… in The Journal of Headache and Pain (2022)

Article

Map** Migraine-Specific Quality of Life to Health State Utilities in Patients Receiving Rimegepant

Migraine is a debilitating neurological condition, affecting up to 15% of Americans. Recent estimates from a long-term safety study of rimegepant showed evidence of decreased monthly migraine days (MMD) in peo...

Karissa M. Johnston, Gilbert L’Italien, Evan Popoff, Lauren Powell… in Advances in Therapy (2021)

Article

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

Mira A. Patel, Jennifer E. Kim, Debebe Theodros… in Journal for ImmunoTherapy of Cancer (2016)

Article

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

Glioblastoma (GBM) is a poorly immunogenic neoplasm treated with focused radiation. Immunotherapy has demonstrated synergistic survival effects with stereotactic radiosurgery (SRS) in murine GBM. GITR is a co-...

Mira A. Patel, Jennifer E. Kim, Debebe Theodros… in Journal for ImmunoTherapy of Cancer (2016)

Article

Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) is a common psychiatric disorder that produces significant morbidity. The introduction of serotonin reuptake inhibitors in the 1980s represented an important advance in the ...

Christopher Pittenger, John H. Krystal, Vladimir Coric in NeuroRX (2006)