18 Result(s)

Article

Psychometric Validation of the Modified Functional Scale for the Assessment and Rating of Ataxia (f-SARA) in Patients With Spinocerebellar Ataxia

This study aimed to generate evidence to support psychometric validity of the modified functional Scale for the Assessment and Rating of Ataxia (f-SARA) among patients with spinocerebellar ataxia (SCA). Psycho...

Michele Potashman, Evan Popoff, Lauren Powell, Ainsley Mackenzie… in The Cerebellum (2024)

Article

Development and Validation of SCACOMS, a Composite Scale for Assessing Disease Progression and Treatment Effects in Spinocerebellar Ataxia

Spinocerebellar ataxias (SCA) are rare inherited neurodegenerative disorders characterized by a progressive impairment of gait, balance, limb coordination, and speech. There is currently no composite scale tha...

Gilbert L’Italien, Evan Popoff, Basia Rogula, Lauren Powell… in The Cerebellum (2024)

Article

Content Validity of the Modified Functional Scale for the Assessment and Rating of Ataxia (f-SARA) Instrument in Spinocerebellar Ataxia

The functional Scale for the Assessment and Rating of Ataxia (f-SARA) assesses Gait, Stance, Sitting, and Speech. It was developed as a potentially clinically meaningful measure of spinocerebellar ataxia (SCA)...

Michele Potashman, Katja Rudell, Ivanna Pavisic, Naomi Suminski… in The Cerebellum (2024)

Article

Observational Analysis of the Costs Associated with Acute Treatment of Breakthrough Migraine Attacks in Medicaid Patients Using Preventive Therapies

Medications for preventive treatment of migraine reduce migraine frequency, usually measured by a reduction in monthly migraine days (MMD), but generally do not eliminate the need for acute treatment. To asses...

Linda Harris, Tom O’Connell, Jonathan J. Woolley, Gilbert L’Italien… in Advances in Therapy (2023)

Article

Health State Utility Map** of Rimegepant for the Preventive Treatment of Migraine: Double-Blind Treatment Phase and Open Label Extension (BHV3000-305)

The objectives of this study were to (1) report long-term health-related quality of life (HRQoL) outcomes among patients using rimegepant preventatively in BHV3000-305 (NCT03732638) open-label extension (OLE) ...

Lauren C. Powell, Gilbert L’Italien, Evan Popoff, Karissa Johnston… in Advances in Therapy (2023)

Article

Measuring interictal burden among people affected by migraine: a descriptive survey study

Previous research has extensively documented the impact of migraine episodes (‘ictal’) on patients’ health-related quality of life. Few studies have looked at the impact of migraine on migraine-free days (‘int...

Lena T. Hubig, Timothy Smith, Emma Williams… in The Journal of Headache and Pain (2022)

Article

Real-World experience of interictal burden and treatment in migraine: a qualitative interview study

The debilitating nature of migraine attacks is widely established; however, less is known about how the interictal burden (i.e., how patients are affected in-between migraine episodes) of migraine impacts on p...

Siu Hing Lo, Katy Gallop, Timothy Smith, Lauren Powell… in The Journal of Headache and Pain (2022)

Article

Monthly migraine days, tablet utilization, and quality of life associated with Rimegepant – post hoc results from an open label safety study (BHV3000–201)

The objective of this study was to describe patterns in monthly migraine days (MMD) and tablet utilization, and to estimate health-related quality of life (HRQoL) measures in patients treated as needed (PRN) w...

Karissa Johnston, Linda Harris, Lauren Powell… in The Journal of Headache and Pain (2022)

Article

The burden of medication overuse headache and patterns of switching and discontinuation among triptan users: a systematic literature review

A synthesis of real-world discontinuation and switching patterns among triptan users and rates of acute medication use among patients with medication overuse headache (MOH) is needed to better understand the b...

Alison M. Deighton, Linda A. Harris, Karissa Johnston, Shomari Hogan… in BMC Neurology (2021)

Article

Map** Migraine-Specific Quality of Life to Health State Utilities in Patients Receiving Rimegepant

Migraine is a debilitating neurological condition, affecting up to 15% of Americans. Recent estimates from a long-term safety study of rimegepant showed evidence of decreased monthly migraine days (MMD) in peo...

Karissa M. Johnston, Gilbert L’Italien, Evan Popoff, Lauren Powell… in Advances in Therapy (2021)

Article

Correction to: A Framework for Estimating the Eligible Patient Population for New Migraine Acute Therapies in the United States

Linda Harris, Gilbert L’Italien, Thomas O’Connell, Zacharia Hasan… in Advances in Therapy (2021)

Article

A Framework for Estimating the Eligible Patient Population for New Migraine Acute Therapies in the United States

Migraine is associated with considerable disability for patients not adequately managed with current standards of care. New acute therapies may offer relief for this population of patients; however, population...

Linda Harris, Gilbert L’Italien, Thomas O’Connell, Zacharia Hasan… in Advances in Therapy (2021)

Article

Economic Impact of Early-in-Hospital Diagnosis and Initiation of Eculizumab in Atypical Haemolytic Uraemic Syndrome

Atypical haemolytic uraemic syndrome (aHUS) is a rare, potentially life-threatening condition caused by dysregulation of the complement pathway. Eculizumab is currently the only approved treatment for this dis...

Michael Ryan, Bonnie M. K. Donato, William Irish, Christoph Gasteyger… in PharmacoEconomics (2020)

Article

Polymorphisms near the IFNL3 Gene Associated with HCV RNA Spontaneous Clearance and Hepatocellular Carcinoma Risk

The aims of this study were to investigate associations between single nucleotide polymorphisms (SNPs) near the genes IFNL2, IFNL3 and IFNL4 and spontaneous clearance of hepatitis C virus (HCV) and to evaluate va...

Mei-Hsuan Lee, Hwai-I Yang, Sheng-Nan Lu, Yu-Ju Lin, Chin-Lan Jen… in Scientific Reports (2015)

Article

Incidence and cost of treatment-emergent comorbid events in insured patients with chronic hepatitis C virus infection: a retrospective cohort study

Treatment-emergent comorbid events (TECs) are common In patients initiating treatment with pegylated interferon alpha (PEG-IFN-alfa) and ribavirin for chronic hepatitis C virus (HCV) infection. The purpose of ...

Sandhya Sapra, Eunice Chang, Michael S Broder… in BMC Health Services Research (2014)

Article

Measurement properties of the Flu-Like Symptom Index from the Hepatitis Physical Symptom Severity Diary

Chronic Hepatitis C (CHC) Virus infection is a serious health issue in the US. Standard treatment involves peginterferon alpha and ribavirin, often associated with adverse side effects including flu-like symp...

Susan Mathias, Ross D. Crosby, Martha S. Bayliss… in Quality of Life Research (2014)

Article

Review of patient-reported outcome measures in chronic hepatitis C

Chronic hepatitis C (CHC) and its treatment are associated with a variety of patient-reported symptoms and impacts. Some CHC symptoms and impacts may be difficult to evaluate through objective clinical testing...

Leah Kleinman, Sally Mannix, Yong Yuan… in Health and Quality of Life Outcomes (2012)

Article

The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913)

The aim of this paper is to evaluate the effect of antipsychotics for the treatment of schizophrenia in a community based study on sexual function and prolactin levels comparing the use of aripiprazole and sta...

Linda Hanssens, Gilbert L'Italien, Jean-Yves Loze, Ronald N Marcus… in BMC Psychiatry (2008)