-
Article
Open AccessCorrection to: Classical structural identifiability methodology applied to low-dimensional dynamic systems in receptor theory
-
Article
Open AccessClassical structural identifiability methodology applied to low-dimensional dynamic systems in receptor theory
Mathematical modelling has become a key tool in pharmacological analysis, towards understanding dynamics of cell signalling and quantifying ligand-receptor interactions. Ordinary differential equation (ODE) mo...
-
Chapter and Conference Paper
Understanding the Form of the Input pressure of Focused Ultrasound in the Rayleigh-Plesset Equation to Improve Drug Delivery Efficiency
To improve the drug delivery efficiency in the brain, the combination of the focused ultrasound (FUS) with microbubbles (MBs) shows a great potential to increase the permeability of the blood-brain barrier (BB...
-
Article
Open AccessThe 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions
We have developed a 3D brain unit network model to understand the spatial-temporal distribution of a drug within the brain under different (normal and disease) conditions. Our main aim is to study the impact o...
-
Article
Open AccessOptimization of Cancer Treatment in the Frequency Domain
Thorough exploration of alternative dosing frequencies is often not performed in conventional pharmacometrics approaches. Quantitative systems pharmacology (QSP) can provide novel insights into optimal dosing ...
-
Article
Open AccessThe need for mathematical modelling of spatial drug distribution within the brain
The blood brain barrier (BBB) is the main barrier that separates the blood from the brain. Because of the BBB, the drug concentration-time profile in the brain may be substantially different from that in the b...
-
Article
Open AccessInfluence of geometrical variations on morphodynamic equilibria in short tidal basins
The existence of cross-sectionally averaged morphodynamic equilibria of tidal inlets is investigated, using a cross-sectionally averaged model, and their sensitivity to variations of geometry, deposition param...
-
Article
Open AccessCorrection to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
The original version of this article was published open access. Unfortunately, due to a technical issue, the copyright holder name in the online version (HTML and XML) is incorrectly published as “Springer Sci...
-
Article
Open AccessModelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
Drug–target binding kinetics (as determined by association and dissociation rate constants, kon and koff) can be an important determinant of the kinetics of drug action. However, the effect compartment model is u...
