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Article
Book review
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Article
The mechanism of antiproliferative activity of the oxaliplatin pyrophosphate derivative involves its binding to nuclear DNA in cancer cells
(1R,2R-diaminocyclohexane)(dihydropyrophosphato) platinum(II), also abbreviated as RRD2, belongs to a class of potent antitumor platinum cytostatics called phosphaplatins. Curiously, several published studies ...
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Article
Open AccessStabilization of human telomeric RNA G-quadruplex by the water-compatible optically pure and biologically-active metallohelices
RNA G-quadruplexes have been suggested to play key roles in fundamental biological processes and are linked to human diseases. Thus, they also represent good potential therapeutic targets. Here, we describe, u...
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Article
Synthesis, antiproliferative activity in cancer cells and DNA interaction studies of [Pt(cis-1,3-diaminocycloalkane)Cl2] analogs
The search for more effective platinum anticancer drugs has led to the design, synthesis, and preclinical testing of hundreds of new platinum complexes. This search resulted in the recognition and subsequent F...
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Article
Correction to: Antimicrobial activity and DNA/HSA interaction of fluorinated 3,6,9-trisubstituted acridines
Online First version of this article was made available online
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Antimicrobial activity and DNA/HSA interaction of fluorinated 3,6,9-trisubstituted acridines
A series of four new 3,6,9-trisubstituted acridine derivatives (two with fluorine substituents on phenyl ring) were synthesized and their interaction with calf thymus DNA and HSA was investigated using a combi...
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Article
Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand
The adverse side effects and acquired resistance associated with the clinical application of traditional platinum-based anticancer drugs have forced investigation of alternative transition metal-based compound...
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Article
Open AccessAn anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis
Conventional chemotherapy is mostly effective in the treatment of rapidly-dividing differentiated tumor cells but has limited application toward eliminating cancer stem cell (CSC) population. The presence of a...
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Article
A new 4-(pyridinyl)-4H-benzo[g]chromene-5,10-dione ruthenium(II) complex inducing senescence in 518A2 melanoma cells
2-Amino-5,10-dihydro-5,10-dioxo-4(pyridine-3-yl)-4H-benzo[g]chromene-3-carbonitrile 5, a cytotoxic lawsone derivative, was reacted with [Ru(p-cymene)Cl2]2 to afford a new Ru(II) ‘piano-stool’ complex 6 which diff...
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Article
Open AccessEpigenetic and antitumor effects of platinum(IV)-octanoato conjugates
We present the anticancer properties of cis, cis, trans-[Pt(IV)(NH3)2Cl2(OA)2] [Pt(IV)diOA] (OA = octanoato), Pt(IV) derivative of cisplatin containing two OA units appended to the axial positions of a six-coordi...
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Article
Open AccessInhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes
Nuclear DNA is the target responsible for anticancer activity of platinum anticancer drugs. Their activity is mediated by altered signals related to programmed cell death and the activation of various signalin...
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Article
Open AccessIron(II) supramolecular helicates interfere with the HIV-1 Tat–TAR RNA interaction critical for viral replication
The interaction between the HIV-1 transactivator protein Tat and TAR (transactivation responsive region) RNA, plays a critical role in HIV-1 transcription. Iron(II) supramolecular helicates were evaluated for ...
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Article
The stability of DNA intrastrand cross-links of antitumor transplatin derivative containing non-bulky methylamine ligands
Oligonucleotides modified by clinically ineffective trans-diamminedichloridoplatinum(II) (transplatin) have been shown to be effective modulators of gene expression. This is so because in some nucleotide sequence...
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Article
Insight into the toxic effects of cis-dichloridoplatinum(II) complexes containing 7-azaindole halogeno derivatives in tumor cells
The cisplatin analogues cis-[PtCl2(3ClHaza)2] (1) and cis-[PtCl2(3IHaza)2] (2) (3ClHaza and 3IHaza are 3-chloro-7-azaindole and 3-iodo-7-azaindole, respectively) are quite toxic to ovarian tumor cells, with moder...
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Article
Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity
The synthesis and characterization of complexes [(η6-arene)Ru(N,N′)X][PF6], where arene is para-cymene (p-cym), biphenyl (bip), ethyl benzoate (etb), hexamethylbenzene (hmb), indane (ind) or 1,2,3,4-tetrahydronap...
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Article
Antitumor carboplatin is more toxic in tumor cells when photoactivated: enhanced DNA binding
Carboplatin, an analogue of “classical” cis-diamminedichloridoplatinum(II) (cisplatin), is a widely used second-generation platinum anticancer drug. Cytotoxicity of cisplatin and carboplatin is mediated by platin...
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Article
Antitumor bifunctional dinuclear PtII complex BBR3535 forms interduplex DNA cross-links under molecular crowding conditions
When antitumor platinum drugs react with DNA they form various types of intrastrand and interstrand cross-links (CLs). One class of new antitumor platinum compounds comprises bifunctional PtII compounds based on ...
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Article
Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear PtII complexes
The effects of major DNA intrastrand cross-links of antitumor dinuclear PtII complexes [{trans-PtCl(NH3)2}2-μ-{trans-(H2N(CH2)6NH2(CH2)2NH2(CH2)6NH2)}]4+ (1) and [{PtCl(DACH)}2-μ-{H2N(CH2)6NH2(CH2)2NH2(CH2)6NH2)}...
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Article
Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity
The helicates—chiral assemblies of two or more metal atoms linked by short or relatively rigid multidentate organic ligands—may be regarded as non-peptide mimetics of α-helices because they are of comparable s...
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Article
DNA adducts of antitumor cisplatin preclude telomeric sequences from forming G quadruplexes
We studied the effect of antitumor cisplatin and inefficient transplatin on the structure and stability of G quadruplexes formed by the model human telomere sequence 5′-GGG(TTAGGG)3-3′ using circular dichroism, U...
