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  1. No Access

    Article

    Asymmetric triplex metallohelices with high and selective activity against cancer cells

    Small cationic amphiphilic α-helical peptides are emerging as agents for the treatment of cancer and infection, but they are costly and display unfavourable pharmacokinetics. Helical coordination complexes may...

    Alan D. Faulkner, Rebecca A. Kaner, Qasem M. A. Abdallah, Guy Clarkson… in Nature Chemistry (2014)

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    Article

    Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity

    The helicates—chiral assemblies of two or more metal atoms linked by short or relatively rigid multidentate organic ligands—may be regarded as non-peptide mimetics of α-helices because they are of comparable s...

    Suzanne E. Howson, Albert Bolhuis, Viktor Brabec, Guy J. Clarkson… in Nature Chemistry (2012)