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Article
Open AccessMetabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting
The identification of novel targets is of paramount importance to develop more effective drugs and improve the treatment of non-small cell lung cancer (NSCLC), the leading cause of cancer-related deaths worldw...
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Article
Open AccessThe role of miR-200b/c in balancing EMT and proliferation revealed by an activity reporter
Since their discovery, microRNAs (miRNAs) have been widely studied in almost every aspect of biology and medicine, leading to the identification of important gene regulation circuits and cellular mechanisms. H...
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Article
Open AccessThymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer
Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT’s different functional aspects in non...
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NFκB activation demarcates a subset of hepatocellular carcinoma patients for targeted therapy
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death worldwide. It is a heterogeneous disorder and >80 % of the tumors develop in patients with liver cirrh...
