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Article
Open AccessTNF-α and IFN-γ gene variation and genetic susceptibility to type 1 diabetes and its microangiopathic complications
TNF-α has accelerating role in development of type 1 diabetes. Although an immunosupressor function and leading protecting role in T1DM also has been claimed for this pro-inflammatory cytokine. Over-expression...
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Article
Open AccessTGF-β1 and IGF-I gene variations in type 1 diabetes microangiopathic complications
Growth factors are generally believed to have a perpetuating role in the development of diabetic complications, However there is ample of evidence of a protective or therapeutic potential for some of them. IGF...
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Article
Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers
Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by unpredictable and variable clinical course. Etiology of MS involves ...
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Article
VEGF gene polymorphism association with diabetic neuropathy
Vascular factors beside metabolic problems are involved in both etiopathogenesis of diabetic neuropathy, and more remarkably, later in “repair” phase, that governs the net balance between neuro-regenerative/de...