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Article
ACE I/D gene polymorphisms and polycystic ovary syndrome manifestations
Polycystic ovary syndrome (PCOS) is a common multifactorial endocrine disorder affecting women of reproductive age. ACE enzyme is involved in the physiopathology of the ovarian system, and there are inconsiste...
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Article
Association of the APOE gene variants with depression in type 2 diabetes
The risk of depression among patients with diabetes is higher than the general population. The exact mechanisms linking these two diseases are mostly unknown. Energy metabolism disorders seem to be a shared pa...
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Article
Investigating the relationship between the VNTR variant of the interleukin-1 receptor antagonist gene and coronary in-stent restenosis
This study aimed to examine the association between the interleukin-1 receptor antagonist gene (IL-1RN) and coronary in-stent restenosis (ISR) through the analysis of the VNTR variant based on the previously r...
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Article
Association of ACE gene polymorphisms with in-stent restenosis by stent type (biomime, supraflex, xience)
Angiotensin Converting Enzyme or ACE is an exo-peptidase that causes the conversion of angiotensin I to angiotensin II, vasoconstriction, and aldosterone production. ACE gene polymorphism (I/D) affects enzyme ...
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Article
Open AccessMetformin and long non-coding RNAs in breast cancer
Breast cancer (BC) is the second most common cancer and cause of death in women. In recent years many studies investigated the association of long non-coding RNAs (lncRNAs), as novel genetic factors, on BC ris...
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Article
Relationship between a near Melanocortin-4 receptor gene variant and puberty timing in children is vague unlike obesity
Obesity is a complicated phenomenon which is a combination of genetic, environmental, and psychological factors. Genetic factors of obesity play an important role in individual risk. It is well known that obes...
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Article
The vitamin D receptor gene variants, ApaI, TaqI, BsmI, and FokI in diabetic foot ulcer and their association with oxidative stress
To date, numerous disorders have been linked to vitamin D deficiency. Several lines of evidence indicate a relationship between vitamin D deficiency and the risk of develo** type 2 diabetes. It has been post...
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Article
Adenosine deaminase gene variant in diabetes and obesity
Personal medicine is a new notion for individualizing treatment in the future. Studying pathogenic markers including genetic variants would be beneficial in better diagnosis and management of complex diseases ...
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Chapter
Precision Medicine Initiatives
The field of precision medicine is emergent and altering at a very growing pace. As the immense scope of initiative programs are currently underway or scheduled in the field of precision medicine in many count...
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Article
Investigation of TGF-β1 gene variant and expression in a group of Iranian women with endometriosis
Endometriosis is defined as a common gynecologic and inflammatory disease. Transforming growth factor-beta 1 (TGF-β1) gene and its protein level might play a role in the pathogenesis of endometriosis. The present...
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Article
ADA gene haplotype is associated with coronary-in-stent-restenosis
Cardiovascular diseases (CVDs) are the most common and the first cause of death worldwide. While some studies have investigated the association of the Adenosine Deaminase (ADA) gene with CDVs, its roles on in-ste...
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Article
Genetic research in Immunogenetics Group of Endocrinology and Metabolism Research Institute
Due to the high prevalence of metabolic diseases and the role of genetic factors in their susceptibility, the use of basic research in this field can be useful for screening, prevention, and treatment of metab...
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Article
Thyroid Cancer research at endocrinology and metabolism research institute (EMRI): a report of scientific activities between 2005 and 2020
Endocrinology and Metabolism Research Institute (EMRI), Tehran University of Medical Sciences, has achieved many advances in the understanding of epidemiology, pathology, and molecular biology of thyroid cance...
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Article
Comments on and assessment of “The rs498872 polymorphism is associated with an elevated susceptibility to glioma: a meta-analysis of 36,264 subjects”
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Article
Inflammation related miRNAs as an important player between obesity and cancers
The growing trend in addition to their burden, prevalence, and death has made obesity and cancer two of the most concerning diseases worldwide. Obesity is an important risk factor for common types of cancers w...
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Article
Comments on: “Meta-analysis of association between Arg326Gln (rs1503185) and Gln276Pro (rs1566734) polymorphisms of PTPRJ gene and cancer risk”
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Article
Macrophage migration inhibitory factor polymorphism (rs755622) in alopecia areata: a possible role in disease prevention
Alopecia areata (AA) is an organ-specific autoimmune disease that targets the bulb of the hair follicles and results in non-scarring hair loss that can range from patchy lesions to involvement of the entire sc...
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Article
Overall corrections and assessments of “Correlations between TLR polymorphisms and inflammatory bowel disease: a meta-analysis of 49 case-control studies”
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Article
Open AccessAutoimmune Polyglandular Syndrome Type 1: a case report
Mutations of the autoimmune regulator gene (AIRE), located on chromosome 21q22.3, are recognized as the cause of a rare monogenic organ-specific autoimmune disorder called autoimmune polyglandular syndrome typ...
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Article
Association of vascular endothelial growth factor (VEGF) Gene polymorphisms and expression with the risk of endometriosis: a case–control study
Endometriosis is a polygenic and multifactorial gynecology situation which might be associated with angiogenesis. In the current study we assess the role of vascular endothelial growth factor (VEGF) − 2578 A/C, a...
