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  1. No Access

    Article

    Comparative Analysis of MPTP Neurotoxicity in Mice with a Constitutive Knockout of the α-Synuclein Gene

    Aggregated forms of α-synuclein are core components of pathohistological inclusions known as Lewy bodies in substantia nigra (SN) neurons of patients with Parkinson’s disease (PD). The role of α-synuclein in s...

    K. D. Chaprov, E. V. Teterina, A. Yu. Roman, T. A. Ivanova… in Molecular Biology (2021)

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    Article

    Increased Expression of the Multimerin-1 Gene in α-Synuclein Knokout Mice

    Multimerin-1 (Mmrn-1) is a soluble protein, also known as elastin microfibril interfacer 4 (EMILIN-4), found in platelets and in the endothelium of blood vessels. Its function and role in pathology are still n...

    K. D. Chaprov, V. V. Goloborshcheva, T. V. Tarasova… in Doklady Biological Sciences (2020)

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    Article

    Synuclein Deficiency Decreases the Efficiency of Dopamine Uptake by Synaptic Vesicles

    In the present study, we analyzed the uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the dorsal striatum of mice with constitutive inactivation of all three...

    N. N. Ninkina, T. V. Tarasova, K. D. Chaprov… in Doklady Biochemistry and Biophysics (2019)