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Article
Comparative Analysis of MPTP Neurotoxicity in Mice with a Constitutive Knockout of the α-Synuclein Gene
Aggregated forms of α-synuclein are core components of pathohistological inclusions known as Lewy bodies in substantia nigra (SN) neurons of patients with Parkinson’s disease (PD). The role of α-synuclein in s...
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Article
Increased Expression of the Multimerin-1 Gene in α-Synuclein Knokout Mice
Multimerin-1 (Mmrn-1) is a soluble protein, also known as elastin microfibril interfacer 4 (EMILIN-4), found in platelets and in the endothelium of blood vessels. Its function and role in pathology are still n...
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Article
Synuclein Deficiency Decreases the Efficiency of Dopamine Uptake by Synaptic Vesicles
In the present study, we analyzed the uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the dorsal striatum of mice with constitutive inactivation of all three...