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  1. Article

    Open Access

    Development of a core outcome set for the evaluation of interventions to enhance trial participation decisions on behalf of adults who lack capacity to consent: a mixed methods study (COnSiDER Study)

    Trials involving adults who lack capacity to provide consent rely on proxy or surrogate decision-makers, usually a family member, to make decisions about participation. Interventions to enhance proxy decisions...

    V. Shepherd, F. Wood, M. Robling, E. Randell, K. Hood in Trials (2021)

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  2. Article

    Open Access

    Effects of various food ingredients on gall bladder emptying

    The emptying of the gall bladder in response to feeding is pivotal for the digestion of fat, but the role of various food ingredients in contracting the gall bladder postprandially is not well understood. We h...

    L Marciani, E F Cox, C L Hoad, J J Totman… in European Journal of Clinical Nutrition (2013)

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  3. No Access

    Article

    Loci other than 21q22.12 (RUNX1) and 16q21–23.2 cause familial AML

    G S Sellick, K Pritchard-Jones, V Shepherd, J Swansbury, D Catovsky… in Leukemia (2005)

  4. No Access

    Article

    Mechanosensory ion channels in charophyte cells: the response to touch and salinity stress

    Mechanosensitive (MS) ion channels are activated by mechanical stress and then transduce this information into electrical signals. These channels are involved in the growth, development and response to enviro...

    V. Shepherd, M. Beilby, T. Shimmen in European Biophysics Journal (2002)

  5. No Access

    Article

    A low CD34+ cell dose results in higher mortality and poorer survival after blood or marrow stem cell transplantation from HLA-identical siblings: should 2 × 106 CD34+ cells/kg be considered the minimum threshold?

    We studied the effect of the CD34+ cell dose on transplant-related mortality (TRM) and survival in 39 patients randomized to receive lenograstim-mobilized PBSCT (n= 20) or BMT (n = 19) from HLA-identical siblings...

    S Singhal, R Powles, J Treleaven, S Kulkarni, B Sirohi… in Bone Marrow Transplantation (2000)

  6. No Access

    Article

    Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in second remission – long-term follow-up

    From 1984 to 1996, 31 consecutive children without sibling donors, aged 5–19 years (median 8) with acute lymphoblastic leukaemia (ALL) in second complete remission (CR), received unpurged autologous bone marro...

    SJ Vaidya, A Atra, S Bahl, CR Pinkerton, V Calvagna… in Bone Marrow Transplantation (2000)

  7. No Access

    Article

    Comparison of marrow and blood cell yields from the same donors in a double-blind, randomized study of allogeneic marrow vs blood stem cell transplantation

    Forty healthy adult donors underwent marrow (BM) as well as peripheral blood (PBSC) stem cell collections for their HLA-identical adult siblings with hematologic malignancies. BM was harvested on day 1 (target...

    S Singhal, R Powles, S Kulkarni, J Treleaven, B Sirohi… in Bone Marrow Transplantation (2000)

  8. No Access

    Article

    The importance of CD34+/CD33− cells in platelet engraftment after intensive therapy for cancer patients given peripheral blood stem cell rescue

    The study was designed to determine whether the number of CD34+/CD33− cells given at autologous peripheral blood stem cell (PBSC) rescue after intensive therapy for cancer was a better predictor of platelet engra...

    BC Millar, JL Millar, V Shepherd, P Blackwell, H Porter… in Bone Marrow Transplantation (1998)

  9. No Access

    Article

    High-dose busulphan/melphalan with autologous stem cell rescue in Ewing’s sarcoma

    Eighteen patients with poor risk Ewing’s sarcoma (including 11 patients with metastatic disease at presentation) received consolidation therapy of busulphan and melphalan with autologous stem cell rescue. Ther...

    A Atra, JS Whelan, V Calvagna, AG Shankar, S Ashley… in Bone Marrow Transplantation (1997)

  10. No Access

    Article

    Outcome assessment of a population-based group of 195 unselected myeloma patients under 70 years of age offered intensive treatment

    A single centre series of 195 consecutive newly diagnosed untreated myeloma patients under 70 years, seen between September 1986 and March 1994, were analysed to assess the impact of current intensive treatmen...

    R Powles, N Raje, S Milan, B Millar, V Shepherd, J Mehta… in Bone Marrow Transplantation (1997)

  11. No Access

    Article

    Comparison of marrow vs blood-derived stem cells for autografting in previously untreated multiple myeloma

    Sixty-three new untreated patients with multiple myeloma under the age of 70 years received C-VAMP induction treatment followed by high-dose intravenous melphalan (200 mg m(-2)) and autologous stem cell transp...

    N Raje, R Powles, C Horton, B Millar, V Shepherd, G Middleton… in British Journal of Cancer (1997)

  12. No Access

    Article

    Compartmentation of fluorescent tracers injected into the epidermal cells of Egeria densa leaves

    We have compared the movement of a series of fluorescent tracers of increasing molecular weight injected into the cytoplasm in the epidermal cells of leaves of Egeria densa Planch. In general, the tracers showed ...

    P. B. Goodwin, V. Shepherd, M. G. Erwee in Planta (1990)

  13. No Access

    Chapter and Conference Paper

    Regulation of Electrical Activity in the Myometrium of the Pregnant Ewe

    Periodic contractions have been recorded from the uterus of many species during pregnancy (Taverne et al. 1979; Germain et al. 1982; Bell 1983; Demianczuk et al. 1984). In ewes, two contractions per hour occur...

    G. D. Thorburn, H. C. Parkington, G. Rice, G. Jenkin… in The Endocrine Control of the Fetus (1988)