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Article
Biodistribution of 177Lu-DOTA-PSMA in Mice with Prostate Carcinoma 22Rv1
Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer and is a well-studied target for therapy of this pathology with PSMA-specific radioligands. The aim of this work was to study the b...
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Article
Biodistribution of 213Bi–Metallothionein and 213Bi–IgG in Intact Mice
One of the important problems of radiopharmaceutics is the development of new approaches for the creation of radiopharmaceuticals based on antibodies while maintaining their specificity and affinity for antige...
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Article
PSMA-Targeted Radiopharmaceuticals for Imaging and Therapy of Prostate Cancer
Molecular changes in prostate cancer lead to increased expression of prostate-specific membrane antigen (PSMA), which is a suitable target for imaging and therapy using radiopharmaceuticals. Data on the most e...
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Article
Radioligand Therapy of Patients with Metastatic Castrate-Resistant Prostate Cancer
Prostate cancer is a serious social and medical problem all over the world. It ranks fifth in the total structure of cancer morbidity and second in the structure of morbidity and mortality of men with neoplasm...
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Article
Biodistribution of Osteotropic 177Lu-EDTMP – a Potential Radiopharmaceutical for Radionuclide Therapy of Bone Metastases
Phosphonates labeled with beta-emitting radionuclides are widely used in nuclear medicine for palliative therapy of bone metastases. This work was aimed at studying the biodistribution of a new osteotropic ant...
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Article
Compartmental Modeling of the Kinetics of 188Re-Labeled Pentaphosphonic Acid in Rats with Bone Callus
Phosphonic acids labeled with rhenium-188 (188Re) are promising bone-seeking radiopharmaceuticals (RPs) for bone metastases therapy. The present work was aimed to develop a compartmental mathematical model of 188
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Article
Biodistribution of 68Ga-NODA-Aminoglucose in Intact and Tumor-Bearing Mice
We studied the biodistribution of 68Ga-NODA-aminoglucose (68Ga-NODA-AG) in normal mice and mice with experimental model of colon adenocarcinoma tumor. It was shown that 68Ga-NODA-aminoglucose was retained in the ...
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Article
BEHAVIORAL FEATURES OF GALLIUM-68 RADIONUCLIDE INCORPORATED IN GLUCOSE DERIVATIVES IN LABORATORY ANIMALS
This work is devoted to a comparative study of pharmacokinetic properties of complex compounds labeled with gallium-68 aminoglucose (68Ga-NODA-AG) or thioglucose (68Ga-NODA-TG) in BALB/c mice after intravenous ad...
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Article
A Comparative Study of the Pharmacokinetics of Bis- and Pentaphosphonic Acids Labeled with Gallium-68 in Rats with Experimental Model of Bone Callus
We analyzed biodistribution of 68Ga-labeled hydroxyethylidenediphosphonic acid (68Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (68Ga-DTPMP) in Wistar rats with experimental model of bone call...
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Article
Behavior of gallium-68 incorporated in NODA aminoglucose in laboratory animals with various pathological processes
Comparative results of the study of the biological distribution of 68Ga incorporated in NODA aminoglucose in mice organs and tissues with the experimental model of malignant tumor and aseptic inflammation are pre...
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Article
Experimental Study of the Biodistribution of New Bone-Seeking Compounds Based on Phosphonic Acids and Gallium-68
We investigate biodistribution of gallium-labeled hydroxyethylidenediphosphonic acid (68Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (68Ga-DTPMP) in intact Wistar rats. It was shown that 68Ga...
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Article
Effect of Gallium Carrier in 68Ga-Ethylenediaminetetrakis (Methylene Phosphonic Acid) on its Behavior in Laboratory Animals
This paper concerns the study of the effect of the stable gallium carrier and its concentration on the biodistribution of a new osteotropic compound based on N,N,N′N′-ethylenediaminetetrakis (methylene phospho...
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Article
Open AccessNuclear nanomedicine using Si nanoparticles as safe and effective carriers of 188Re radionuclide for cancer therapy
Nuclear nanomedicine, with its targeting ability and heavily loading capacity, along with its enhanced retention to avoid rapid clearance as faced with molecular radiopharmaceuticals, provides unique opportuni...
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Article
Complex Compounds of Rhenium-188 and Gallium-68 Radionuclides and Their Behavior in the Organism of Laboratory Animals
This paper concerns the study of pharmacokinetic properties of rhenium-188 and gallium-68 bound to a ligand based on tetraphosphonic acid (188 Re,68 Ga-EDTMP). The pharmacokinetics of 188 Re,68 Ga-EDTMP is studie...
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Article
Pharmacokinetics in Intact Rats of N,N,N′,N′-Ethylenediaminetetrakis-(Methylenephosphonic Acid) Labeled with Gallium-68
Pharmacokinetic studies of the new bone-seeking radiopharmaceutical (RP) 68Ga-labeled N,N,N′,N′-ethylenediaminetetrakis(methylenephosphonic acid) (EDTMP) for PET diagnosis of bone metastases showed that 68Ga-EDTM...
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Article
18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review)
This review addresses progress in the radionuclide diagnosis of oncological diseases using radiopharmaceutical preparations (RPP) based on labeled glucose derivatives. Most attention is paid to 2-[18F]fluoro-2-de...
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Article
Radiopharmaceuticals Based on Polyaminophosphonic Acids Labeled with α−, β−, and γ-Emitting Radionuclides (Review)
This review presents results on the pharmacokinetic characteristics of osteotropic radiopharmaceuticals (RP) based on polyaminophosphonic acids labeled with various radionuclides. The greatest number of studie...
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Article
The Pharmacokinetics of Technetium-99m-Labeled N,N,N′,N′-Ethylenediaminetetra-Kis-(Methylenephosphonic Acid) in Intact Rats
Pharmacokinetic studies of technetium-99m-labeled N,N,N′,N′-ethylenediaminetetra-kis-(methylenephosphonic acid) (99mTc-EDTMP) showed that this radiopharmaceutical (RP) has high in vivo stability. Studies of the b...
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Article
Pharmacokinetic Study of the New Diagnostic Radiopharmaceutical 99mTc-Pentaphosphonic Acid in Rats with an Experimental Bone-Fracture Model
The pharmacokinetic properties of a bone-seeking radiopharmaceutical based on pentaphosphonic acid labeled with technetium-99m (99mTc-PPA) were investigated. The experiments were performed in healthy rats and in ...
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Article
Pharmacokinetic Characteristics of the Radiopharmaceutical “188Re-Albumin Microspheres” After Intravenous Administration to Laboratory Animals
Studies of the pharmacokinetics of 188Re-human serum albumin microspheres (MSA) of diameter 10 – 20 μm in intact mice showed that the maximum accumulation of activity (about 70%) 5 min at after intravenous admini...
