40 Result(s)

Article

Studies of the Pharmacokinetics of Actinium-255-Labeled Bisphosphonate in Intact Mice

The pharmacokinetics of ²²⁵Ac-labeled hydroxyethylenediphosphoric acid monopotassium salt (²²⁵Ac-KHEDP) and ²²⁵AcCl₃ were studied in intact mice after intravenous administration. The results obtained here showed ...

V. M. Petriev, V. K. Podgorodnichenko… in Pharmaceutical Chemistry Journal (2013)

Article

Pharmacokinetics of ¹⁸⁸Re-labeled pentaphosphonic acid in rats with experimental bone callosity

The influence of modeled femur callosity on the biodistribution of ¹⁸⁸Re-labeled pentaphosphonic acid (¹⁸⁸Re-PPA) in rats was studied. The radiopharmaceutical was injected into a tail vein 14 d after fracture. It...

V. K. Shiryaeva, V. M. Petriev, O. A. Smoryzanova… in Pharmaceutical Chemistry Journal (2013)

Article

Evaluation of the influence of preparation conditions on pharmacokinetics of bone-seeking radiopharmaceutical ¹⁸⁸Re-labeled hydroxyethylidenediphosphonic acid monopotassium salt in rats

The in vivo biodistributions of the monopotassium salt of hydroxyethylidenediphosphonate labeled with ¹⁸⁸Re (¹⁸⁸Re-KHEDP) were studied in rats for drug batches prepared with and without Re carrier. Also, the phar...

V. K. Shiryaeva, V. M. Petriev, A. A. Bryukhanova… in Pharmaceutical Chemistry Journal (2012)

Article

Pharmacokinetics of a new radiopharmaceutical based on alubmin microspheres and palladium-103 and modified by heat and radiation

The pharmacokinetics of albumin microspheres (AMS) labeled with ¹⁰³Pd (¹⁰³Pd-AMS) were studied in healthy mice after intramuscular injections. It was established that increasing the denaturation temperature of al...

V. M. Petriev, V. K. Shiryaev, V. G. Skvortsov… in Pharmaceutical Chemistry Journal (2011)

Article

Comparative analysis of pharmacokinetic characteristics of radiopharmaceuticals based on the monopotassium salt of 1-hydroxyethylidenediphosphonic acid labeled by ^99mT9c and ¹⁸⁸Re

Investigation of pharmacokinetic characteristics of the ^99mTc- and ¹⁸⁸Re-labeled monopotassium salt of 1-hydroxyethylidenediphosphonic acid (KHEDP) in rats showed that the level of accumulated activity at 5 min a...

V. K. Shiryaeva, V. M. Petriev, A. A. Bryukhanova… in Pharmaceutical Chemistry Journal (2011)

Article

Development of a procedure for preparing ¹⁰³Pd-microspheres of human blood albumin, a potential radiopharmaceutical for treatment of malignant tumors

Sorption of Pd by albumin microspheres (AMSs) largely depends on the HCl concentration, reaching a maximum at an HCl concentration of 0.08 M. Sorption of Pd grows with an increase in its equilibrium concentrat...

V. M. Petriev, V. K. Shiryaev, L. A. Smakhtin, V. G. Skvortsov in Radiochemistry (2010)

Article

Regular trends in complexation of ¹⁸⁸Re with human blood albumin microspheres

A study of regular trends in the complexation of ¹⁸⁸Re with denatured albumin in microspheres (AMSs) prepared by dispersing a solution of human blood albumin in olive oil with continuous stirring and heating to 1...

V. M. Petriev in Radiochemistry (2009)

Article

Osteotropic radiopharmaceuticals based on phosphonic acids for the treatment of bone metastases in humans (review)

This review describes the advantages and disadvantages of radionuclides used in the development of radiopharmaceuticals for radionuclide therapy. Comparison of the characteristics of various radionuclides lead...

V. M. Petriev, E. L. Afanas’eva, V. G. Skvortsov in Pharmaceutical Chemistry Journal (2008)

Article

Effects of ⁶⁰Co whole-body γ-irradiation in different doses on the distribution of ¹⁸⁸Re-labeled autologous mesenchymal stem cells in Wistar rats after intravenous (systemic) transplantation during different periods after exposure

The effects of whole-body γ-irradiation in different doses on the distribution of ¹⁸⁸Re-labeled mesenchymal stem cells obtained by culturing of the rat bone marrow cells were studied in different organs and tissu...

A. G. Konoplyannikov, V. M. Petriev… in Bulletin of Experimental Biology and Medic… (2008)

Article

Influence of reactant concentrations and solution acidity on the complexation of ¹⁸⁸Re with 1-hydroxyethane-1,1-diphosphonic acid

Specific features of the complexation of ¹⁸⁸Re with 1-hydroxyethane-1,1-diphosphonic acid (HEDP) were studied in relation to the solution acidity and reactant concentrations. The reaction rate and efficiency of t...

V. M. Petriev in Radiochemistry (2008)

Article

Distribution of sodium perrenate in intact mice

The distribution of sodium perrenate (Na¹⁸⁸ReO₄) in the organism of intact mice has been studied. It is shown that the behavior of Na¹⁸⁸ReO₄ in the organism depends on the method of administration. In particular,...

V. M. Petriev, O. A. Smoryzanova, V. G. Skvortsov in Pharmaceutical Chemistry Journal (2007)

Article

Immunoglobulin: DNA cofactor interaction

The reasons for the appearance of DNA-binding activity of immunoglobulins (Ig) after chromatography on anion-exchange Sephadexes were studied. Elution of Ig from these Sephadexes with 0.5 M NaCl was found, usi...

M. K. Malinka, V. M. Petriev, V. K. Podgorodnichenko in Pharmaceutical Chemistry Journal (2007)

Article

Influence of Sn²⁺ concentration on complexation of ^99m Tc with potassium sodium hydroxyethylidenediphosphonate

Kinetics of formation of a ^99m Tc complex with potassium sodium hydroxyethylidenediphosphonate (KNaHEDP) was studied. Since the Tc reduction competes with the Tc reoxidation at low Sn²⁺/Sn⁴⁺ conce...

V. M. Petriev, V. G. Skvortsov, T. P. Ryzhikova in Radiochemistry (2007)

Article

Influence of the rhenium carrier in eluate of Re-188 on its binding with potassium-sodium salt of hydroxyethylidene biphosphonic acid

The results of investigation of the regularity of ¹⁸⁸Re binding with KNaHEDP and hydrolysis of the complex compound (¹⁸⁸Re-KNaHEDP) have shown that its quality depends to a considerable extent on the reaction con...

V. M. Petriev, E. L. Afanasieva, V. G. Skvortsov… in Czechoslovak Journal of Physics (2006)

Article

Influence of the rhenium carrier in eluate of Re-188 on its binding with potassium-sodium salt of hydroxyethylidene biphosphonic acid

The results of investigation of the regularity of ¹⁸⁸Re binding with KNaHEDP and hydrolysis of the complex compound (¹⁸⁸Re-KNaHEDP) have shown that its quality depends to a considerable extent on the reaction con...

V. M. Petriev, E. L. Afanasieva, V. G. Skvortsov… in Czechoslovak Journal of Physics (2006)

Article

Neutron Activation Preparation of ¹⁶⁶Ho-Albumin Microspheres as a Promising Radiopharmaceutical for Tumor Therapy

A procedure of activation with thermal neutrons of ¹⁶⁵Ho incorporated in the particle matrix was developed for preparing human blood albumin microspheres (AMs) labeled with ¹⁶⁶Ho. Since the specific activity of ^1...

V. M. Petriev, V. G. Skvortsov, L. A. Smakhtin, T. P. Ryzhikova in Radiochemistry (2005)

Article

Monitoring of Radionuclide Impurities in ¹⁶⁶Ho-Albumin Microspheres Prepared by Neutron Activation with Thermal Neutrons

Analysis of radionuclide impurities in ¹⁶⁶Ho-albumin microspheres prepared by activation with thermal neutrons of ¹⁶⁵Ho preliminarily incorporated in the particle matrix was performed. The content of impurities i...

V. M. Petriev, V. G. Skvortsov, L. A. Smakhtin, I. N. Shutova in Radiochemistry (2005)

Article

Production of [⁵⁷Co]bleomycetin and study of its kinetics in the bodies of intact animals and tumor-bearing animals

V. M. Petriev, Dzh G. Khachirov, R. M. Prusova in Pharmaceutical Chemistry Journal (1982)

Article

Pharmacokinetics of [^99mTc]acetylmethionine in the organism of tumor-bearing animals

Dzh G. Khachirov, V. M. Petriev, Yu. I. Savin… in Pharmaceutical Chemistry Journal (1979)

Article

Preparation of N-C₄-[¹²⁵I]pyrazolylmethyltetracycline and study of its behavior in the organism of intact and tumor-bearing animals

Dzh G. Khachirov, V. M. Petriev, P. P. Filatov… in Pharmaceutical Chemistry Journal (1979)