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  1. No Access

    Article

    Melanopsin signalling in mammalian iris and retina

    Non-mammalian vertebrates have an intrinsically photosensitive iris and thus a local pupillary light reflex (PLR). In contrast, it is thought that the PLR in mammals generally requires neuronal circuitry conne...

    T. Xue, M. T. H. Do, A. Riccio, Z. Jiang, J. Hsieh, H. C. Wang, S. L. Merbs… in Nature (2011)

  2. No Access

    Chapter

    An Introduction on TRP Channels

    The transient receptor potential (TRP) ion channels are named after the role of the channels in Drosophila phototransduction. Mammalian TRP channel subunit proteins are encoded by at least 28 genes. TRP cation ch...

    V. Flockerzi in Transient Receptor Potential (TRP) Channels (2007)

  3. No Access

    Chapter

    Cell-Free Synthesis of Membrane Proteins on a Preparative Scale

    Our attempts to produce some mammalian membrane proteins of interest to us in E. coli failed miserably. Therefore, we tried to synthesize these proteins in the rapid translation system (RTS), an E.coli-based cell...

    Dr. Patrick Maurer, A. Moratzky, C. Fecher-Trost… in Cell-Free Protein Expression (2003)

  4. No Access

    Article

    Characterisation of explanted endothelial cells from mouse aorta: electrophysiology and Ca2+ signalling

    We describe here the isolation and primary culture of endothelial cells from mouse aorta ("primary explant technique"). These cells provide an excellent model for functional studies in transgenic mice. The pr...

    S.H. Suh, R. Vennekens, V.G. Manolopoulos, M. Freichel, U. Schweig… in Pflügers Archiv (1999)

  5. No Access

    Chapter

    High-Voltage Activated Ca2+ Channel

    Calcium channels are part of the signal system which is vital for intercellular communication in higher multicellular organisms. They transduce electrical or hormonal signals into a chemical second messenger, ...

    F. Hofmann, M. Biel, E. Bosse, R. Hullin, P. Ruth, A. Welling… in GTPases in Biology II (1993)

  6. No Access

    Chapter and Conference Paper

    Tissue distribution and possible function of the subunits of the L-type calcium channels

    L-type calcium channels are present in many tissues and are the major pathway for voltage activated calcium entry in heart and smooth muscle and are essential for EC-coupling in skeletal muscle. The transverse...

    F. Hofmann, M. Biel, R. Hullin, E. Bosse… in Intracellular Regulation of Ion Channels (1992)

  7. No Access

    Chapter and Conference Paper

    The Structure of the Skeletal and Nonskeletal Muscle Calcium Channel

    A number of fundamental biological processes such as mobility, secretion, and neurotransmission are regulated by a change in the cytosolic calcium concentration. The cytosolic calcium concentration is raised f...

    F. Hofmann, P. Ruth, T. Schneider, J. Felbel… in Molecular Mechanisms of Hormone Action (1989)

  8. No Access

    Chapter and Conference Paper

    Site-Specific Phosphorylation of the Skeletal Muscle Receptor for Calcium-Channel Blockers by cAMP-Dependent Protein Kinase

    Voltage-operated calcium channels are important factors in excitation-contraction coupling of cardiac and smooth muscle. The cardiac L-type calcium channel was the first channel known to be modified by hormone...

    A. Röhrkasten, H. E. Meyer, T. Schneider… in The Calcium Channel: Structure, Function a… (1988)

  9. No Access

    Chapter and Conference Paper

    Reconstitution of Solubilized and Purified Dihydropyridine Receptor from Skeletal Muscle Microsomes as Two Single Calcium Channel Conductances with Different Functional Properties

    Calcium entry through voltage-sensitive calcium channels (VSCC) is a vital link between membrane depolarization and cellular function (Hille 1984). In many excitable cells, the entry of Ca2+ ions can be inhibi...

    D. Pelzer, A. Cavalié, V. Flockerzi… in The Calcium Channel: Structure, Function a… (1988)

  10. No Access

    Chapter and Conference Paper

    Biochemistry and Physiology of Cardiac Calcium Channels

    The voltage-dependent slow calcium channel allows the passive movement of calcium across the plasma membrane of a variety of excitable cells and regulates thereby directly or indirectly the cytosolic calcium c...

    F. Hofmann, V. Flockerzi, J. Oeken, P. Ruth in Neurobiochemistry (1985)

  11. No Access

    Article

    Injection of catalytic subunit of cAMP-dependent protein kinase into isolated cardiac myocytes

    Cyclic adenosine 3′,5′-monophosphate (cAMP) or the free catalytic subunit (C) of the cAMP-dependent protein kinase were pressure injected into single guinea pig ventricular cells. The following results were ob...

    G. Brum, V. Flockerzi, F. Hofmann, W. Osterrieder, W. Trautwein in Pflügers Archiv (1983)

  12. No Access

    Article

    Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current

    β-Adrenergic stimulation of the heart is thought to increase cardiac muscle contractility by activation of cyclic AMP-dependent protein kinase and concomitant increase in the phosphorylation of certain proteins.....

    W. Osterrieder, G. Brum, J. Hescheler, W. Trautwein, V. Flockerzi, F. Hofmann in Nature (1982)

  13. No Access

    Article

    Injection of isolated subunits of cAMP-dependent protein kinase II into single adult cardiac myocytes modulates the slow Ca++ inward current

    W. Osterrieder, G. Brum, J. Hescheler, W. Trautwein, V. Flockerzi… in Pflügers Archiv (1982)

  14. No Access

    Chapter

    Purification And Characterisation Of A cGMP-Dependent Protein Kinase From Bovine Heart Muscle

    Guanosine 3′: 5′-momophosphate-dependent protein kinase from bovine heart muscle was purified to apparent homogeneity using affinity chromatography. The kinase activity was purified at least 16.400-fold with a...

    V. Flockerzi, N. Speichermann, F. Hofmann in Deutsche Pharmakologische Gesellschaft (1978)