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Article
Synthesis, structure, and cytotoxicity of platinum(iv) complexes bearing aminoxyl and dichloroacetate ligands
New platinum(iv)-aminoxyl complexes (PACs) 2a,b, bearing an aminoxyl radical with antioxidant properties in the equatorial position and axial dichloroacetate ligands capable of inhibiting the energy production in...
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Article
The Increase of Antileukemic Efficiency of Doxorubicin and Other Cytostatics Combined with Platinum(IV)-Nitroxyl Complex ВС118
Combined treatment of murine leukemia P388 with doxorubicin and platinum(IV)-nitroxyl complex ВС118 administered in low doses improved efficiency of treatment (cure of 83% of animals) without increasing toxicity.
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Article
Kinetics of superoxide-initiated reaction of nitroxides with cysteine
Kinetics of the reduction of nitroxides with cysteine in the presence of a source of superoxide radicals was studied. The reactivity of nitroxides in this process is determined by the reduction potential of th...
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Article
Influence of Tumor Suppressor p53 Functioning on the Expression of Antioxidant System Genes under the Action of Cytotoxic Compounds
The effect of inhibition of the tumor suppressor p53 on the antioxidant system genes expression under the influence of cytotoxic compounds of the platinum group was studied. It was found that the action of pla...
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Article
Comparison of the Effect of Platinum (IV) Complexes on Spheroids and Monolayer Culture of HeLa Cells
We performed a comparative study of the cytotoxicity of cisplatin, JM216 complex, and aminonitroxyl platinum(IV) complexes for HeLa cells grown in monolayer and 3D culture. The growth dynamics of spheroids was...
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Article
Polymer nanoparticles of N-vinylpyrrolidone loaded with an organic aminonitroxyl platinum (iv) complex. Characterization and investigation of their in vitro cytotoxicity
The conditions for obtaining stable aqueous solutions of a lipophilic aminonitroxyl platinum complex, namely, e-amine-d-(4-amino-2,2,6,6-tetramethylpiperidine 1-oxyl)-a, f-bis(octanoato)-b, c-dichloroplatinum(iv)...
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Article
Effect of Chitosan-(Poly)Nitroxides on Normal and Tumor Cells under Conditions of Induced Oxidative Stress
The cytotoxicity and antioxidant effects of chitosan-(poly)nitoxides of different molecular weights containing a nitroxide radical of the piperidine structure were studied on tumor (HeLa, A172, and HepG2) and ...
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Article
Antioxidant properties of chitosan-(poly)nitroxides under induced oxidative stress
The cytotoxicity and antioxidant properties of water-soluble (at physiological pH) chitosan- (poly)nitroxides (CPNs) containing pyrroline-based nitroxide and having different molecular weights of the polysacch...
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Article
Superoxide radicals in the kinetics of nitroxide-inhibited oxidation of methyl linoleate in micelles
The kinetics of the oxidation of methyl linoleate in micelles inhibited by stable nitroxides under the conditions of initiation by superoxide radicals was studied. Multiple breakdown of the oxidation chains wa...
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Article
Effect of superoxide dismutase on the oxidation of methyl linoleate in micelles inhibited by nitroxyl radicals
The kinetics of oxidation of methyl linoleate in micelles inhibited by stable nitroxyl radicals in the presence of superoxide dismutase was studied. In the presence of superoxide dismutase, nitroxyl radicals d...
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Article
Effect of Cytotoxic Compounds on Activity of Antioxidant Enzyme System in MCF-7 and H1299 Cells
We studied the function of the antioxidant system in tumor cell lines MCF-7 and H1299 that differ by the state of tumor suppressor gene p53. Exposure to different classes of cytotoxic compounds induced several...
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Article
Stable nitroxyl radicals and hydroxylamines as inhibitors of methyl linoleate oxidation in micelles
The kinetics of methyl linoleate oxidation in micelles inhibited by nitroxyl radicals and hydroxylamines was studied. The regeneration of nitroxyl radicals in this process was found. The activity of the studie...
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Article
Multiple chain termination by aromatic nitroxides in oxidation of styrene
The antioxidant activity of aromatic nitroxides in the oxidation of styrene was studied using a complex of kinetic methods in combination with quantum chemical calculations and kinetic modeling. During oxidati...
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Article
Synthesis and structure of redox derivatives of 4-(2-Amino-2-oxoethyl)-2,2,6,6-tetramethylpiperidine-1-yloxyl
According to X-ray diffraction (XRD) analysis and 1H NMR spectra 2-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)acetamide, 4-(2-amino-2-oxoethyl)-2,2,6,6-tetramethylpiperidin-1-yloxyl, and 4-(2-amino-2-oxoethyl)-...
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Article
Acid-catalyzed disproportionation of N,N-bis(4-tert-butylphenyl)hydroxylamine. Synthesis and structure of 10-[5-tert-butyl-2-(4-tert-butylphenylamino)phenyl]-3,7-di-tert-butylphenoxazine
New method of synthesis was developed for N,N-bis(4-tert-butylphenyl)hydroxylamine by reduction of the corresponding aminoxyl with hydrazine hydrate. At the treatment with strong acids this hydroxylamine derivati...
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Article
Reductive chlorination of bis(4-tert-butylphenyl)amine-N-oxyl nitroxyl radical
Unlike cyclic aliphatic nitroxyls, whose oxidation with halogens gives oxoammonium salts, bis(4-tert-butylphenyl)amine-N-oxyl (1) treated with chlorine undergoes reductive chlorination to the corresponding di- an...
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Article
Oxidation and reductive bromination of Bis(4-tert-butylphenyl)aminoxyl
One-electron oxidation of bis(4-tert-butylphenyl)aminoxyl with antimony pentachloride and bromine leads to the formation of oxoammonium salts with anions SbCl 6 − ...
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Article
Preparative syntheses of bis(4-tert-butylphenyl)aminoxyl
Bis(4-tert-butylphenyl)aminoxyl was obtained in 80 and 95% yield by oxidation of the corresponding amine and hydroxylamine with H2O2/WO 4 2− in methanol at 65°...
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Article
Mechanism of autoreduction of bis(4-methoxyphenyl)-oxoammonium perchlorate in aqueous alkali
Autoreduction of bis(4-methoxyphenyl)oxoammonium perchlorate in aqueous alkali follows a mechanism different from that generally accepted for diaryloxoammonium salts. Bis(4-methoxyphenyl)-oxoammonium cation un...
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Article
Synergistic antitumor effect of cisplatin and the platinum(iv) nitroxyl complex BC118 and the development of resistance to their combined action
The efficacy of the combination treatment of P388 leukemia with cisplatin (cPt) and the platinum(IV) nitroxyl complex BC118 [e-ammine-d-(4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl)-a,f-bis(acetato)-b,c-dichloro...
