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  1. Article

    Propylene Glycol Pharmacokinetics and Renal Elimination Capacity: Preliminary Observations

    Introduction: Unintended propylene glycol (PG) administration (34 mg/kg/24h) did not affect postnatal adaptations [1]. Subsequently, we aim to document PG disposition in neonates.

    A Kulo, V Cossey, J N De Hoon, R Verbesselt, K Allegaert in Pediatric Research (2011)

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  2. Article

    473 Prospective Evaluation of Propylene Glycol Tolerance in (PRE) Term Neonates: An Active Comparator Approach

    Introduction: Propylene glycol (PG) is a commonly used excipiens although accumulation can result in hyperosmolarity, renal toxicity and lactic acidosis. This is of concern in neonates given their limited meta...

    K Allegaert, J D Hoon, M Rayyan, R Verbesselt, V Cossey, G Naulaers in Pediatric Research (2010)

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  3. Article

    7 Ontogeny of Udp-Glucuronosyltransferase Activity During Repeated Administration of Propacetamol in Neonates

    Background: Major changes in drug clearance are observed during infancy, at least partially based on ontogenic regulation of metabolic pathways but data on maturation of UDP-glucuronosyltransferase (UGT)-activity...

    K Allegaert, D Tibboel, H Devlieger, J de Hoon, R Verbesselt… in Pediatric Research (2004)

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    Article

    About the rationale of the insertion of a Heimlich valve in the thoracostomy circuit in newborn infants and small children

    H. Devlieger, C. Vanhole, A. Debeer, V. Cossey, K. Allegaert… in Intensive Care Medicine (2001)