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Article
Propylene Glycol Pharmacokinetics and Renal Elimination Capacity: Preliminary Observations
Introduction: Unintended propylene glycol (PG) administration (34 mg/kg/24h) did not affect postnatal adaptations [1]. Subsequently, we aim to document PG disposition in neonates.
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Article
473 Prospective Evaluation of Propylene Glycol Tolerance in (PRE) Term Neonates: An Active Comparator Approach
Introduction: Propylene glycol (PG) is a commonly used excipiens although accumulation can result in hyperosmolarity, renal toxicity and lactic acidosis. This is of concern in neonates given their limited meta...
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Article
7 Ontogeny of Udp-Glucuronosyltransferase Activity During Repeated Administration of Propacetamol in Neonates
Background: Major changes in drug clearance are observed during infancy, at least partially based on ontogenic regulation of metabolic pathways but data on maturation of UDP-glucuronosyltransferase (UGT)-activity...