53 Result(s)

Article

Klug entscheiden in der Inneren Medizin

„Klug entscheiden“ ist eine Initiative der Deutschen Gesellschaft für Innere Medizin (DGIM) zur Stärkung der Indikationsqualität. Zusammen mit zwölf internistischen Schwerpunkten bzw. assoziierten Fachgesellsc...

Prof. Dr. G. Hasenfuß, E. Märker-Hermann, M. Hallek, U. R. Fölsch in Der Internist (2016)

Article

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)

An elevated proteasome activity contributes to tumorigenesis, particularly by providing cancer cells with antiapoptotic protection and efficient clearance from irregular proteins. Still, the underlying mechani...

A Arlt, I Bauer, C Schafmayer, J Tepel, S Sebens Müerköster, M Brosch, C Röder… in Oncogene (2009)

Article

The apoptosis-inducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-κB inhibition

Addressing the puzzling role of amidated gastrin₁₇ (G17) and the gastrin/CCKB/CCK2 receptor in colorectal carcinogenesis, we analysed potential candidate genes involved in G17-dependent NF-κB inhibition and apopt...

S Sebens Müerköster, A V Rausch, A Isberner, J Minkenberg, E Blaszczuk, M Witt… in Oncogene (2008)

Chapter and Conference Paper

Genomweite Untersuchung identifiziert den hepatischen Cholesterol Transporter ABCG8 als Suszeptibilitäts-Faktor für das humane Gallensteinleiden

Gallstone disease is a common disorder with a prevalence of approximately 20 % in industrialized countries. We performed a genome-wide disease association scan of over 500,000 single nucleotide polymorphisms (...

Dr. med. Clemens Schafmayer MBA, S. Buch, J. Egberts… in Chirurgisches Forum 2008 (2008)

Chapter

Physiology and Pathophysiology of Endocrine Pancreatic Secretion

B. Gallwitz, U. R. Fölsch in Diseases of the Pancreas (2008)

Article

Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells

Pancreatic ductal adenocarcinoma (PDAC) is characterized by rapid tumor progression, high metastatic potential and profound chemoresistance. We recently reported that induction of a chemoresistant phenotype in...

S Sebens Müerköster, V Werbing, B Sipos, M A Debus, M Witt, M Großmann… in Oncogene (2007)

Article

Acquired chemoresistance in pancreatic carcinoma cells: induced secretion of IL-1β and NO lead to inactivation of caspases

Pancreatic cancer exhibits profound chemoresistance resulting either from pre-existing (intrinsic) mechanisms, or from anticancer drug treatment itself (acquired chemoresistance). To identify molecular alterat...

S Sebens Müerköster, J Lust, A Arlt, R Häsler, M Witt, T Sebens, S Schreiber… in Oncogene (2006)

Article

CED richtig behandeln!

Der Altersgipfel in der Erstmanifestation chronisch entzündlicher Darmerkrankungen (M. Crohn, Colitis ulcerosa) liegt im Adoleszenz- und frühen Erwachsenenalter. Auf Grund des lebenslangen, chronisch rezidivie...

Prof. Dr. S. Schreiber, U. R. Fölsch, S. Nikolaus in CME (2005)

Article

The expression of immediate early gene X-1 (IEX-1) is differentially induced by retinoic acids in NB4 and KG1 cells: possible implication in the distinct phenotype of retinoic acid-responsive and -resistant leukemic cells

In a cell-type- and stimulus-dependent fashion, the early response gene immediate early gene X-1 (IEX-1) is involved in growth control and modulation of apoptosis. The present study demonstrates that, in the two ...

A Arlt, J Minkenberg, B Kocs, M Großmann, M-L Kruse, U R Fölsch, H Schäfer in Leukemia (2004)

Article

Genetik und Umwelt

S. Schreiber, J. Hampe, J. Grebe, S. Nikolaus, M. Stoll, U. R. Fölsch in Der Internist (2002)

Article

Kompetenznetz chronisch-entzündliche Darmerkrankungen

U. R. Fölsch, J. Hoffmann, W. Höhne, K.-H. Janke, B. Klump, G. Rogler… in Der Internist (2002)

Article

Functional anatomy of the papilla Vateri

Background: Problems with intubation of the ampulla Vateri during diagnostic and therapeutic endoscopic maneuvers are a well-known feature. The ampulla Vateri was analyzed three-dimensionally to determine whet...

F.P. Paulsen, T. Bobka, M. Tsokos… in Surgical Endoscopy And Other Interventiona… (2002)

Article

Pharmacogenetic investigation of the TNF/TNF-receptor system in patients with chronic active Crohn's disease treated with infliximab

Infliximab (anti-TNF-α monoclonal antibody) induces remission in 30–40% of Crohn's disease patients. Treatment response is a stable trait. Two cohorts from independent, prospective clinical trials of inflixima...

S Mascheretti, J Hampe, T Kühbacher, H Herfarth, M Krawczak… in The Pharmacogenomics Journal (2002)

Article

Primäre Nebennierenrindeninsuffizienz und subklinische neurologische Veränderungen bei einem jungen Mann

S. Kloehn, T. Arendt, W. Köhler, U. R. Fölsch, H. Mönig in Der Internist (2000)