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Article
Identification of the Inhibition Effects of Some Natural Antiproliferative Agents on CA-I, CA-II, and AChE Activities Isolated from Human Erythrocytes by Kinetic and Molecular Docking Studies
Nowadays the determination of inhibitors of carbonic anhydrase isoenzymes (CAs) have become one of the main goals of drug design studies, and inhibitors of CAs have taken their place in clinical applications t...
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Article
Open AccessIsolated tumor cells in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival
Lymph node (LN) involvement represents the strongest prognostic factor in colon cancer patients. The objective of this prospective study was to assess the prognostic impact of isolated tumor cells (ITC, define...
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Article
Discrete Improvement in Racial Disparity in Survival among Patients with Stage IV Colorectal Cancer: a 21-Year Population-Based Analysis
Recently, multiple clinical trials have demonstrated improved outcomes in patients with metastatic colorectal cancer. This study investigated if the improved survival is race dependent.
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Article
Open AccessMolecular staging of lymph node-negative colon carcinomas by one-step nucleic acid amplification (OSNA) results in upstaging of a quarter of patients in a prospective, European, multicentre study
Current histopathological staging procedures in colon carcinomas depend on midline division of the lymph nodes with one section of haematoxylin & eosin (H&E) staining only. By this method, tumour deposits outs...
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Article
Open AccessElevated preoperative CEA is associated with worse survival in stage I–III rectal cancer patients
The objective of this investigation was to assess whether preoperative carcinoembryonic antigen (CEA) level is an independent predictor of overall survival in rectal cancer patients.
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Article
Reihe Evidenzbasierte Chirurgie
Valide Studienergebnisse sind wesentliche Voraussetzung für Akzeptanz und erfolgreiches Praktizieren evidenzbasierter Chirurgie. Die angestrebte Validität ist jedoch ggf. durch verschiedene Formen systematisch...
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Article
Reihe Evidenzbasierte Chirurgie
Systematische Reviews und Metaanalysen sind unverzichtbarer Bestandteil chirurgischer Praxis und Forschung geworden. Sie repräsentieren die höchste mögliche Evidenzstufe und ermöglichen, in kurzer Zeit einen Ü...
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Article
Neurogene Appendicopathie: Ein häufiges, fast unbekanntes Krankheitsbild Auswertung von 816 Appendices und Literaturübersicht
Background: Neurogenic appendicopathy (NA) represents an almost unknown pathology which clinically cannot be differentiated from acute appendicitis. The diagnosis can only be established...
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Chapter and Conference Paper
Neurogene Appendikopathie: Ein häufiges, fast unbekanntes Krankheitsbild / Neurogenic Appendicopathy: A Frequent Yet Unknown Condition
Background: Neurogenic appendicopathy (NA) represents an almost unknown pathology which clinically can not be differentiated from acute appendicitis. Diagnosis can only be established histologi...