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  1. Article

    PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death

    To achieve malignancy, cancer cells convert numerous signaling pathways, with evasion from cell death being a characteristic hallmark. The cell death machinery represents an anti-cancer target demanding consta...

    E-M Schweikert, A Devarajan, I Witte, P Wilgenbus, J Amort… in Cell Death & Differentiation (2012)

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  2. Article

    Open Access

    Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells

    Major contributors to atherosclerosis are oxidative damage and endoplasmic reticulum (ER) stress-induced apoptosis; both of which can be diminished by the anti-oxidative protein paraoxonase-2 (PON2). ER stress...

    I Witte, S Altenhöfer, P Wilgenbus, J Amort, A M Clement, A Pautz… in Cell Death & Disease (2011)

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  3. No Access

    Chapter

    Regulation of Nitric Oxide Synthase Expression and Activity

    Nitric oxide (NO) can control vital functions, such as neurotransmission or vascular tone (via activation of soluble guanylyl cyclase), gene transcription and mRNA translation (via iron-responsive elements), a...

    U. Förstermann in Nitric Oxide (2000)

  4. No Access

    Article

    Mechanism of bradykinin-induced cyclic GMP accumulation in bovine tracheal smooth muscle

    Bradykinin (10−8-10−5M) caused a concentration-dependent increase in cyclic GMP (cGMP) production in bovine tracheal smooth muscle in the absence of epithelium. The effect was calcium-dependent and was inhibited ...

    H. Sheng, K. Ishii, U. Förstermann, F. Murad in Lung (1995)

  5. No Access

    Article

    Differential localization of neuronal nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in the cat spinal cord

    The distributions of neuronal nitric oxide synthase immunoreactivity (NOS-IR) and NADPH-diaphorase (NADPH-d) activity were compared in the cat spinal cord. NOS-IR in neurons around the central canal, in superf...

    M. A. Vizzard, S. L. Erdman, J. R. Roppolo, U. Förstermann… in Cell and Tissue Research (1994)

  6. No Access

    Article

    Nitric oxide synthase in the enteric nervous system of the guinea-pig: a quantitative description

    The distribution and abundance of nitric oxide synthase (NOS)-containing neurons and their terminals in the gastrointestinal tract of the guinea-pig were examined in detail using NADPH diaphorase histochemistr...

    J. B. Furness, Z. S. Li, H. M. Young, U. Förstermann in Cell and Tissue Research (1994)

  7. No Access

    Chapter

    Isoforms of Nitric Oxide Synthase and the Nitric Oxide-Cyclic Gmp Signal Transduction System

    From the work in our laboratory and subsequently other laboratories, it has been known for many years that cyclic GMP induces the relaxation of numerous smooth muscle preparations including vascular, airway an...

    Ferid Murad, U. Förstermann, M. Nakane, J. Pollock, H. Schmidt… in Vascular Endothelium (1993)

  8. No Access

    Chapter

    Analysis of Eicosanoids by GC-MS/MS

    Analysis of eicosanoids in biological matrices is difficult. Their levels are very low, and they are rapidly metabolized to numerous structurally similar substances often found in much higher concentration. He...

    J. C. Frölich, K.-H. Marx, H. Bippi… in Bioanalysis of Drugs and Metabolites, Espe… (1988)

  9. No Access

    Article

    The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia

    The effect of intraluminal hypoxia on vascular tone and the release of prostaglandins (PG) I2 and E2 were investigated in intact isolated segments of canine femoral and coronary arteries as well as in the rat tai...

    R. Busse, U. Förstermann, H. Matsuda, U. Pohl in Pflügers Archiv (1984)

  10. No Access

    Article

    Effect of exogenous and endogenous prostacyclin on the contractility of rabbit splenic capsular smooth muscle

    1. Using sensitive and specific radioimmunoassays release of prostaglandins (PGs) E2, F2α, 6-keto-F1α and thromb...

    T. Simmet, U. Förstermann, B. A. Peskar in Naunyn-Schmiedeberg's Archives of Pharmacology (1980)

  11. No Access

    Article

    The importance of Ca2+-mediated phospholipase A2 activation for stimulus-evoked PGE2-release from rabbit splenic capsular strips

    Rabbit splenic capsular strips released PGE2 when contracted by noradrenaline. Contraction as well as PGE2-release were Ca2+-dependent.

    U. Förstermann, G. Hertting in Naunyn-Schmiedeberg's Archives of Pharmacology (1979)