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Article
Open AccessSwallowing-related muscle inflammation and fibrosis induced by a single dose of radiation exposure in mice
Although radiotherapy is commonly used to treat head and neck cancer, it may lead to radiation-associated dysphagia (RAD). There are various causes of RAD, however, the mechanism has not yet been fully identif...
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Article
Open AccessStructures of a FtsZ single protofilament and a double-helical tube in complex with a monobody
FtsZ polymerizes into protofilaments to form the Z-ring that acts as a scaffold for accessory proteins during cell division. Structures of FtsZ have been previously solved, but detailed mechanistic insights ar...
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Article
Open AccessAlpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection
Activation of the cholinergic anti-inflammatory pathway (CAP) via vagus nerve stimulation has been shown to improve acute kidney injury in rodent models. While alpha 7 nicotinic acetylcholine receptor (α7nAChR...
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Article
Open AccessEvaluation of oral care using MA-T gel for high-risk patients: a pilot study
Oral care with gel is a common method for preventing aspiration in high-risk patients. An oral care gel is used to clean and moisturize the oral cavity. However, the effects of gel care on the oral bacteria re...
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Article
Open AccessEpoxidized graphene grid for highly efficient high-resolution cryoEM structural analysis
Functionalization of graphene is one of the most important fundamental technologies in a wide variety of fields including industry and biochemistry. We have successfully achieved a novel oxidative modification...
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Article
Open AccessAnimal species identification utilising DNAs extracted from traditionally manufactured gelatin (Wanikawa)
Gelatin, sourced from collagen, is an acid-, alkali- or enzymatically hydrolysed product obtained from animal skins and bones. Gelatin has been widely used for the manufacture of various cultural objects, e.g....
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Article
Open AccessA panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron
We are amid the historic coronavirus infectious disease 2019 (COVID-19) pandemic. Imbalances in the accessibility of vaccines, medicines, and diagnostics among countries, regions, and populations, and those in...
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Article
Open AccessNeuroimmune system-mediated renal protection mechanisms
The autonomic nervous system plays an important role in maintaining homeostasis in organisms. Recent studies have shown that it also controls inflammation by directly altering the function of the immune system...
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Article
Open AccessNovel neutralizing human monoclonal antibodies against tetanus neurotoxin
Tetanus is a fatal disease caused by tetanus neurotoxin (TeNT). TeNT is composed of a light chain (Lc) and a heavy chain, the latter of which is classified into two domains, N-terminus Hn and C-terminus Hc. Se...
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Article
Open AccessVagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration
The efficacy of prior activation of an anti-inflammatory pathway called the cholinergic anti-inflammatory pathway (CAP) through vagus nerve stimulation (VNS) has been reported in renal ischemia-reperfusion inj...
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Article
Adaptive feedforward cancellation with gain and dam** control system considering helium leakage in HDDs
This study developed an adaptive feedforward cancellation system with gain and dam** control for hard disk drives (HDDs). The system was developed to compensate for fluid-induced vibration due to helium leak...
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Article
Open AccessA RuBisCO-mediated carbon metabolic pathway in methanogenic archaea
Two enzymes are considered to be unique to the photosynthetic Calvin–Benson cycle: ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), responsible for CO2 fixation, and phosphoribulokinase (PRK). Some arch...
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Article
Open AccessEffects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells
The effects of chronic low-dose radiation on human health have not been well established. Recent studies have revealed that neural progenitor cells are present not only in the fetal brain but also in the adult...
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Article
Open AccessCross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements
Synergistic transcriptional activation by different stimuli has been reported along with a diverse array of mechanisms, but the full scope of these mechanisms has yet to be elucidated.
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Article
Open AccessTargeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells
The acquisition of endocrine resistance is a common obstacle in endocrine therapy of patients with oestrogen receptor-α (ERα)-positive breast tumours. We previously demonstrated that the BIG3–PHB2 complex has ...
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Article
Open AccessHyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease
One of the best-characterized causative factors of Alzheimer’s disease (AD) is the generation of amyloid-β peptide (Aβ). AD subjects are at high risk of epileptic seizures accompanied by aberrant neuronal exci...
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Chapter and Conference Paper
Web Service Systems for Cooperative Work Support in Knowledge Creation Processes
The emergence of Web service results from the business needs as mentioned below. Web service as the evolution of software engineering is also required to explore the possibility of adapting to cooperative work...
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Article
Erratum: Mechanism of metal activation of human hematopoietic prostaglandin D synthase
Nat. Struct. Biol. 10, 291–296 (2003). The y-axes of Fig. 3a,b,d in this manuscript were labeled incorrectly. The correct unit for the PDGS activity in these panels should be μmol min−1 mg−1 protein. Additiona...
