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Probing Mitotic Chromosome Mechanics Using Optical Tweezers
During mitosis, cells compact their DNA into rodlike shapes, four orders of magnitude shorter than the DNA backbone contour length. We describe an experimental protocol to isolate and study these intricate mit...
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Article
Open AccessPICH acts as a force-dependent nucleosome remodeler
In anaphase, any unresolved DNA entanglements between the segregating sister chromatids can give rise to chromatin bridges. To prevent genome instability, chromatin bridges must be resolved prior to cytokinesi...
