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Article
Open AccessTargeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia
Current therapies that target the B-cell receptor pathway or the inhibition of anti-apoptotic proteins do not prevent the progressive forms of chronic lymphocytic leukemia (CLL), have low long-term efficacy an...
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Article
Open AccessBDNF belongs to the nurse-like cell secretome and supports survival of B chronic lymphocytic leukemia cells
Evading apoptosis and sustained survival signaling pathways are two central hallmarks of B-cell chronic lymphocytic leukemia (B-CLL) cells. In this regard, nurse-like cells (NLC), the monocyte-derived type 2 m...
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Article
Open AccessSortilin limits EGFR signaling by promoting its internalization in lung cancer
Tyrosine kinase receptors such as the epidermal growth factor receptor (EGFR) transduce information from the microenvironment into the cell and activate homeostatic signaling pathways. Internalization and degr...