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  1. Article

    Open Access

    Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia

    Current therapies that target the B-cell receptor pathway or the inhibition of anti-apoptotic proteins do not prevent the progressive forms of chronic lymphocytic leukemia (CLL), have low long-term efficacy an...

    Léa Ikhlef, May Yassine, Boutaîna Chandouri, Léa Rivière… in Scientific Reports (2024)

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  2. Article

    Open Access

    BDNF belongs to the nurse-like cell secretome and supports survival of B chronic lymphocytic leukemia cells

    Evading apoptosis and sustained survival signaling pathways are two central hallmarks of B-cell chronic lymphocytic leukemia (B-CLL) cells. In this regard, nurse-like cells (NLC), the monocyte-derived type 2 m...

    Hugo Talbot, Sofiane Saada, Elodie Barthout, Paul-François Gallet… in Scientific Reports (2020)

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  3. Article

    Open Access

    Sortilin limits EGFR signaling by promoting its internalization in lung cancer

    Tyrosine kinase receptors such as the epidermal growth factor receptor (EGFR) transduce information from the microenvironment into the cell and activate homeostatic signaling pathways. Internalization and degr...

    Hussein Al-Akhrass, Thomas Naves, François Vincent… in Nature Communications (2017)

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