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Chapter
G-CSF, GM-CSF, and IL-3 Knockout Mice
Granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GMCSF), and interleukin-3 (IL-3) stimulate the proliferation, differentiation, and activation of multiple hemato...
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Article
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production
Mice lacking activity of the kinase MEKK1 ('Map3k1ΔKD' mice) have defective activation of the kinase Jnk and increased production of T helper type 2 cytokines after T cell receptor ligation. Here we show that Map...
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Article
IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ
Pathways dependent on the transcription factor NF-κB provide innate immunity against microbes. Karin and colleagues show that mice lacking the kinase IKKβ have IL-1-dependent neutrophilia. Loss of IL-1 signali...
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Article
Open AccessThe great masquerader of malignancy: chronic intestinal pseudo-obstruction
Paraneoplastic syndromes can precede the initial manifestation and diagnosis of cancer. Paraneoplastic syndromes are a heterogeneous group of disorders caused by mechanisms other than the local presence of tum...
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Article
The Role of Oncolytic Viruses in the Treatment of Melanoma
Oncolytic virotherapy is a new approach to the treatment of cancer and its success in the treatment of melanoma represents a breakthrough in cancer therapeutics. This paper provides a review of the current lit...
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Article
Correction to: The Role of Oncolytic Viruses in the Treatment of Melanoma
A correction was made to a sentence in the original article to provide additional clarification in the “Other Oncolytic Viruses” section.
