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  1. Article

    Open Access

    p73: A Multifunctional Protein in Neurobiology

    p73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development. Indeed, mice deficient for both TAp73 and ΔNp73 isoforms display neuronal pathologie...

    Richard Killick, Maria Niklison-Chirou, Richard Tomasini… in Molecular Neurobiology (2011)

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    Chapter and Conference Paper

    MEK Kinase 1: Kinase Domain Deficiency in Mice Reveals a Role in Orchestrating the Thymus-Dependent Immunity and TNFR Family Signaling

    Almost 20 years ago early work led to the cloning and identification of mitogen-activated protein kinases (MAPKs) as the apical component of a biochemical phospho-relay circuit that is activated by upstream MA...

    Ewen Gallagher in Advances in TNF Family Research (2011)

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    Article

    Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

    Mice lacking activity of the kinase MEKK1 ('Map3k1ΔKD' mice) have defective activation of the kinase Jnk and increased production of T helper type 2 cytokines after T cell receptor ligation. Here we show that Map...

    Ewen Gallagher, Thomas Enzler, Atsushi Matsuzawa, Amy Anzelon-Mills… in Nature Immunology (2007)