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  1. No Access

    Article

    IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

    Pathways dependent on the transcription factor NF-κB provide innate immunity against microbes. Karin and colleagues show that mice lacking the kinase IKKβ have IL-1-dependent neutrophilia. Loss of IL-1 signali...

    Li-Chung Hsu, Thomas Enzler, Jun Seita, Anjuli M Timmer, Chih-Yuan Lee… in Nature Immunology (2011)

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    Article

    Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

    Mice lacking activity of the kinase MEKK1 ('Map3k1ΔKD' mice) have defective activation of the kinase Jnk and increased production of T helper type 2 cytokines after T cell receptor ligation. Here we show that Map...

    Ewen Gallagher, Thomas Enzler, Atsushi Matsuzawa, Amy Anzelon-Mills… in Nature Immunology (2007)