24 Result(s)
within
Thomas C. Register
English
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Article
Female baboon adrenal zona fasciculata and zona reticularis regulatory and functional proteins decrease across the life course
Debate exists on life-course adrenocortical zonal function trajectories. Rapid, phasic blood steroid concentration changes, such as circadian rhythms and acute stress responses, complicate quantification. To a...
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Executive function mediates age-related variation in social integration in female vervet monkeys (Chlorocebus sabaeus)
In humans, social participation and integration wane with advanced age, a pattern hypothesized to stem from cognitive or physical decrements. Similar age-related decreases in social participation have been ob...
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Open AccessCross-species comparative analysis of single presynapses
Comparing brain structure across species and regions enables key functional insights. Leveraging publicly available data from a novel mass cytometry-based method, synaptometry by time of flight (SynTOF), we ap...
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Correction to: Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus)
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Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus)
Dual declines in gait speed and cognitive performance are associated with increased risk of develo** dementia. Characterizing the patterns of such impairments therefore is paramount to distinguishing healthy...
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Open AccessDiet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model
The objective of this study was to increase understanding of the complex interactions between diet, obesity, and the gut microbiome of adult female non-human primates (NHPs). Subjects consumed either a Western (n
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Open AccessGenome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes
Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop C...
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Open AccessIn vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure
Safe clinical hormone replacement (HR) will likely become increasingly important in the growing populations of aged women and cancer patients undergoing treatments that ablate the ovaries. Cell-based HRT (cHRT...
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Relationships of depressive behavior and sertraline treatment with walking speed and activity in older female nonhuman primates
Depression is the most common mental health problem in aging persons and is a leading risk factor for physical disability, especially in women. Though antidepressant drugs such as serotonin reuptake inhibitors...
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Open AccessTranscriptomic profiles of aging in purified human immune cells
Transcriptomic studies hold great potential towards understanding the human aging process. Previous transcriptomic studies have identified many genes with age-associated expression levels; however, small sampl...
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Clinical and Research Applications of Bone Mineral Density Examinations
For over a quarter of a century, various types of examinations measuring bone mineral density (BMD) yielded essential information about bone health and fracture risk and have made a significant impact on osteo...
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Sertraline effects on cerebrospinal fluid monoamines and species-typical socioemotional behavior of female cynomolgus monkeys
Although widely prescribed, little is known about the effects of selective serotonin reuptake inhibitors (SSRIs) on social behavior and cerebrospinal fluid (CSF) monoamines in female primates.
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Open AccessProgestin effects on cell proliferation pathways in the postmenopausal mammary gland
Menopausal hormone therapies vary widely in their effects on breast cancer risk, and the mechanisms underlying these differences are unclear. The primary goals of this study were to characterize the mammary gl...
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Open AccessRelationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study
Monocyte chemoattractant protein-1 (MCP-1) plays important roles in kidney disease susceptibility and atherogenesis in experimental models. Relationships between serum MCP-1 concentration and early nephropathy...
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Aging and physical mobility in group-housed Old World monkeys
While indices of physical mobility such as gait speed are significant predictors of future morbidity/mortality in the elderly, mechanisms of these relationships are not understood. Relevant animal models of ag...
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Effect of race and genetics on vitamin D metabolism, bone and vascular health
Inverse associations between bone mineral density and calcified atherosclerotic plaque are observed in individuals of European and African ancestry without nephropathy, suggesting a mechanistic link between th...
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Life stage differences in mammary gland gene expression profile in non-human primates
Breast cancer (BC) is the most common malignancy of women in the developed world. To better understand its pathogenesis, knowledge of normal breast development is crucial, as BC is the result of disregulation ...
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Article
Open AccessAbdominal aortic calcification quantified by the Morphological Atherosclerotic Calcification Distribution (MACD) index is associated with features of the metabolic syndrome
Abdominal aortic calcifications (AAC) predict cardiovascular mortality. A new scoring model for AAC, the Morphological Atherosclerotic Calcification Distribution (MACD) index may contribute with additional inf...
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Gender-Dependent Correlations of Carotid Intima–Media Thickness with Gene Expression in Blood
The mechanisms underlying gender differences in stroke incidence, risk, and outcome are uncertain. We sought to determine whether transcriptional profiles of circulating blood cells of men and women differenti...
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Open AccessHuman macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes
Proteolytic degradation of Type I Collagen by proteases may play an important role in remodeling of atherosclerotic plaques, contributing to increased risk of plaque rupture.
