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Article
Open AccessThe hippocampus dissociates present from past and future goals
Our brain adeptly navigates goals across time frames, distinguishing between urgent needs and those of the past or future. The hippocampus is a region known for supporting mental time travel and organizing inf...
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Article
Executive function mediates age-related variation in social integration in female vervet monkeys (Chlorocebus sabaeus)
In humans, social participation and integration wane with advanced age, a pattern hypothesized to stem from cognitive or physical decrements. Similar age-related decreases in social participation have been ob...
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Article
Open AccessLongevity factor klotho enhances cognition in aged nonhuman primates
Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and r...
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Article
Processed intraoperative burst suppression and postoperative cognitive dysfunction in a cohort of older noncardiac surgery patients
Postoperative cognitive dysfunction (POCD) is a decline in cognitive test performance which persists months after surgery. There has been great interest in the anesthesia community regarding whether variables ...
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Article
Correction to: Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus)
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Article
Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus)
Dual declines in gait speed and cognitive performance are associated with increased risk of develo** dementia. Characterizing the patterns of such impairments therefore is paramount to distinguishing healthy...
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Article
Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates
The most common chemogenetic neuromodulatory system, designer receptors exclusively activated by designer drugs (DREADDs), uses a non-endogenous actuator ligand to activate a modified muscarinic acetylcholine ...
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Article
Open AccessDelay discounting decisions are linked to temporal distance representations of world events across cultures
Delay discounting describes the phenomenon whereby the subjective value of a reward declines as the time until its receipt increases. Individuals differ in the subjective value that they assign to future rewar...
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Article
Memories light the corners of my mind
Using light-activated ion channels to stimulate sensory and motivational pathways, Vetere and colleagues constructed fully artificial memories in mice. Mice preferred or avoided an odor they had never smelled ...
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Article
Cell- and layer-specific transcriptomic strategy for characterizing the molecular phenotype of rat cortical neurons using laser capture microdissection and massively parallel RNA sequencing
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Article
Open AccessAdolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons
Neuronal circuits within the prefrontal cortex (PFC) mediate higher cognitive functions and emotional regulation that are disrupted in psychiatric disorders. The PFC undergoes significant maturation during ado...
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Article
Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse
Attention is disrupted commonly in psychiatric disorders, yet mechanistic insight remains limited. Deficits in this function are associated with dorsal anterior cingulate cortex (dACC) excitotoxic lesions and ...
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Article
Behavioral control by the orbital prefrontal cortex: reversal of fortune
A study shows that selective lesions of the orbital prefrontal cortex in macaques spare behavioral flexibility and emotional processing but impair a test of outcome expectation, suggesting that some psychiatri...
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Article
The ageing cortical synapse: hallmarks and implications for cognitive decline
Individual differences are a hallmark of cognitive and synaptic ageing. Neurobiological differences between individuals of the same chronological age may under...
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Article
Cholinergic modulation of a specific memory function of prefrontal cortex
Deficits in prefrontal cholinergic function have been implicated in cognitive impairment in many neuropsychiatric diseases. Here, the authors report that monkeys with lesions of cholinergic input to prefrontal...
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Article
Visual perception and memory systems: from cortex to medial temporal lobe
Visual perception and memory are the most important components of vision processing in the brain. It was thought that the perceptual aspect of a visual stimulus occurs in visual cortical areas and that this se...
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Article
Activation of 5-HT6 receptors facilitates attentional set shifting
Prefrontal cortex (PFC)-dependent executive function is disrupted in a range of psychiatric disorders and can be modelled in non-human primates and rodents using attentional set-shifting paradigms. There are f...
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Chapter
Age-Related Effects on Prefrontal Cortical Systems: Translating Between Rodents, Nonhuman Primates, and Humans
Impairments in cognition related to dysfunction of the prefrontal cortex occur as a consequence of aging in rodents, nonhuman primates, and humans. This chapter describes evidence from several different cognit...
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Article
The amygdala and reward
It is widely accepted that the amygdala is associated with fear conditioning and the processing of negative emotions. But this structure is also involved in th...
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Protocol
Effects of Selective Immunotoxic Lesions on Learning and Memory
Immunotoxins provide the opportunity to make neurotoxic lesions of specific neurochemically-defined neuronal populations (see Chapter 17) by targeting cell-surface antigens that are uniquely expressed by the cell...
