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Chapter
Pancreas Cancer
Despite its infrequency, pancreatic cancer is the fourth leading cause of cancer death in USA with an estimated 42,140 new cases and 36,800 deaths projected in the USA for 2010 [1]. Although mortality rates ha...
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Chapter
Primary Colorectal Cancer
Carcinoma of the rectum is a heterogeneous disease. At one end of the clinical spectrum, a small number of patients present with superficially invasive cancers who are well served by limited procedures, such ...
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Chapter
Modern Radiation Therapy Approaches: Targeted and Ablative Strategies
New technological advances in radiation oncology have allowed safe, high dose delivery of radiation therapy with ablative intent. In this chapter, new technologies such as intensity-modulated radiation therapy...
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Article
Open AccessACR Appropriateness Criteria® Resectable Rectal Cancer
The management of resectable rectal cancer continues to be guided by clinical trials and advances in technique. Although surgical advances including total mesorectal excision continue to decrease rates of loca...
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Article
Dosimetric predictors of nausea and vomiting: an exploratory analysis of a prospective phase I/II trial with neoadjuvant accelerated short-course radiotherapy and capecitabine for resectable pancreatic cancer
We performed an exploratory analysis to identify dose-volume parameters that may predict treatment-induced nausea and vomiting among patients receiving hypofractionated radiotherapy to the pancreas.
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Article
Stereotactic body radiation therapy (SBRT) for pancreatic and non-hepatobiliary gastrointestinal (GI) malignancies
In this review article, we review the current literature addressing the use of stereotactic body radiation therapy (SBRT) in non-hepatobiliary gastrointestinal malignancies. For many gastrointestinal malignanc...
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Article
Treatment of Stage II–III Rectal Cancer Patients
The role and sequencing of radiotherapy in the management of T3–4 or node-positive rectal cancer has evolved over the last few decades. Given the significant local failure rate following surgery alone, both pr...
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Chapter
Emerging Techniques in Image-Guided Radiation Therapy and Stereotactic Body Radiation Therapy
Locoregional recurrence is the primary failure pattern for biliary tract and gallbladder cancers. However, the use of external beam radiation therapy in the treatment for these cancers, particularly cholangioc...
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Article
Mutational and Clinical Predictors of Pathologic Complete Response in the Treatment of Locally Advanced Rectal Cancer
Preoperative chemoradiation (CRT) for locally advanced rectal adenocarcinoma achieves pathologic complete response (pCR) in 8–20 % of patients. Mutations in critical cancer genes may contribute to lack of pCR....
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Article
Genetic Mechanisms in Interval Colon Cancers
The factors underlying the development of interval colon cancers are not well defined and are likely heterogeneous. We sought to determine whether there are distinct molecular properties associated with interv...
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Article
Adjuvant Therapy Completion Rates in Patients with Gastric Cancer Undergoing Perioperative Chemotherapy Versus a Surgery-First Approach
Delayed recovery after gastrectomy may preclude the administration of adjuvant therapy in a significant percentage of patients who undergo elective gastrectomy as the initial therapy for gastric cancer. Clinic...
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Article
Advances in the Management of Gastric and Gastroesophageal Cancers
Management of gastric and gastroesophageal cancers is a complex, evolving paradigm. Involvement of multimodality specialties is the key. In gastric cancer, data are conflicting with regard to the specific role...
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Article
Predictors of Lymph Node Metastasis in Western Early Gastric Cancer
The application of endoscopic and local resection for early gastric cancer (EGC) is limited by the risk of regional lymph node (LN) metastasis. We sought to determine the incidence and predictors of LN metasta...
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Chapter
Role of Radiation Therapy for Intrahepatic Cholangiocarcinoma
Intrahepatic cholangiocarcinoma is a rare diagnosis, yet the incidence continues to rise worldwide. As these tumors often clinically present at an advanced stage, the majority of patients have unresectable dis...
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Article
Open AccessPretreatment plasma HGF as potential biomarker for susceptibility to radiation-induced liver dysfunction after radiotherapy
Radiotherapy shows excellent local control in liver cancers but carries the risk of radiation-induced liver dysfunction and liver failure. We conducted a study of plasma hepatocyte growth factor (HGF) in a cli...
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Chapter
Radiotherapy
Intrahepatic cholangiocarcinoma (ICC) is a rare biliary malignancy, with a significant risk of both extensive local progression and distant metastasis. While resection has long stood as the mainstay of curativ...
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Article
A common Chk1-dependent phenotype of DNA double-strand break suppression in two distinct radioresistant cancer types
Triple-negative breast cancers (TNBC) are often resistant to treatment with ionizing radiation (IR). We sought to investigate whether pharmacologic inhibition of Chk1 kinase, which is commonly overexpressed in...
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Article
Open AccessConcurrent therapy with immune checkpoint inhibitors and TNFα blockade in patients with gastrointestinal immune-related adverse events
Immune checkpoint inhibitors (ICI) have demonstrated remarkable efficacy as cancer therapeutics, however, their use remains limited due to the development of immune related adverse events (irAEs). Immune relat...
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Article
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers
During cancer therapy, tumor heterogeneity can drive the evolution of multiple tumor subclones harboring unique resistance mechanisms in an individual patient1–3. Previous case reports and small case series have ...
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Article
Clinical impact of PET/MR in treated colorectal cancer patients
The primary aim of the present study was to evaluate if PET/MR induced management changes versus standard of care imaging (SCI) in treated colorectal cancer patients. The secondary aim was to assess the stagin...
