18 Result(s)
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Article
Open AccessHepatocyte Transplantation: Cell Sheet Technology for Liver Cell Transplantation
We will review the recent developments of cell sheet technology as a feasible tissue engineering approach. Specifically, we will focus on the technological advancement for engineering functional liver tissue u...
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Chapter
Cell Sheet Tissue Engineering for Heart Failure
In recent years, regenerative medicine using cells for treating tissue defects has been in the spotlight as a new treatment for severe heart failure. Direct injection of bone marrow-derived cells and isolated ...
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Article
Cell Sheets for Periodontal Tissue Engineering
Cell Sheet Technology was first utilized in a clinical trial for corneal reconstruction in 2003; since then, several clinical trials have been performed not only in Japan but also in Europe. The key technology...
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Article
Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3
Throughout life, hematopoietic stem cells (HSCs) sustain the blood cell supply through their capacities for self-renewal and multilineage differentiation. These processes are regulated within a specialized mic...
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Article
Development of Eczematous Symptoms by the Implanted Breast Prosthesis
A patient with an unidentified implanted breast prosthesis experienced eczematous symptoms 3 years after implantation, although prosthesis rapture and complications such as capsular contraction, hematoma, and ...
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Article
Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a case
Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by progressive heart failure, and is a leading cause of mortality and morbidity. Recently, cellular therapy for end-stage heart failure has ...
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Article
“Deep-media culture condition” promoted lumen formation of endothelial cells within engineered three-dimensional tissues in vitro
In the field of tissue engineering, the induction of microvessels into tissues is an important task because of the need to overcome diffusion limitations of oxygen and nutrients within tissues. Powerful method...
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Article
Fibroblast sheets co-cultured with endothelial progenitor cells improve cardiac function of infarcted hearts
We have already confirmed that cell sheet transplantation can improve damaged heart function via continuous cytokine secretion. In this study, we hypothesized that cytokine-secreting cell sheets co-cultured wi...
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Chapter and Conference Paper
Retinal Pigment Epithelial Cells from Thermally Responsive Polymer-Grafted Surface Reduce Apoptosis
Brain-derived neurotrophic factor (BDNF) has reported to show photoreceptor protection for retinal degeneration either genetically programmed,1 or light induced experimental retinal degeneration.2 Genetically mod...
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Chapter
Cell Sheet Technology for Myocardial Tissue Engineering
Myocardial tissue regeneration including isolated cell transplantation and recruitment of bone marrow stem cells via cytokines have now emerged as one of the most promising treatments for patients suffering fr...
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Chapter
Clinical Survey of Cell Therapy in Japan
Background: Therapeutic angiogenesis by using cells is being performed in Japan. However, it is unknown in how many centers and how these therapies are performed. The efficacy and side effects are also unknown...
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Chapter and Conference Paper
Highly Blood-Compatible Surface Consisting of a Silicon-Containing Block Copolymer with Supramolecular Structure
With the aim of develo** a high-performance membrane-type artificial lung, a novel silicon-containing hydrophilic-hydrophobic block copolymer was prepared using a living anionic polymerization technique. To ...
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Chapter
Changes in Platelet Metabolism in Contact with Hydrophilic Copolymer Surfaces
The metabolism of platelets in contact with poly(acrylamide-co-methacrylic acid) (PAAmMAc) particles was evaluated in terms of changes in cytoplasmic free calcium levels ([Ca2+]i), aderosine triphosphate (ATP) re...
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Chapter
Improved Patency of HEMA/Styrene Block Copolymer-Coated Small Vessel Prosthesis Without Neointima Formation
We have already demonstrated that an amphi-philic block copolymer composed of 2-hydroxyethyl metha-crylate and styrene (HEMA-st) showed improved blood compatibility in in vitro and ex vivo experiments. The pre...
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Chapter and Conference Paper
Evaluation of cytoplasmic free calcium levels in platelets interacting with polymer surfaces
A quantitative evaluation of platelet activation on polymer surfaces was demonstrated, i.e., direct measurement of cytoplasmic free calcium concentration in platelets in contact with polystyrene latex particle...
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Chapter and Conference Paper
Activation of platelets on well-defined microdomain structures
We have already reported that block copolymers composed of hydroxyethylmethacrylate (HEMA) and styrene (St), having hydrophilic/hydrophobic microdomain structures, demonstrated excellent nonthrombogenicity. In...
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Chapter and Conference Paper
Retrieval analyses of U-100 Total Artificial Heart blood-contacting surface
This paper deals with retrieval analyses of the Utah-100 (U-100) total artificial heart (TAH). Thrombus formation, cell adhesion and activation, mineralization, and adsorbed protein layers have been investigat...
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Chapter
Improved blood compatibility of heparin immobilization and PEO-PDMS-heparin triblock copolymer coating on surfaces of segmented polyurethaneurea
New heparin-immobilized polyurethaneurea surfaces utilizing hydrophilic spacer systems have been developed for in situ surface modification. Surface modification both by hydrophilic grafting of polyethylene ox...
