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  1. No Access

    Article

    High-throughput screening and selection of yeast cell lines expressing monoclonal antibodies

    The methylotrophic yeast Pichia pastoris has recently been engineered to express therapeutic glycoproteins with uniform human N-glycans at high titers. In contrast to the current art where producing therapeutic p...

    Gavin C. Barnard, Angela R. Kull… in Journal of Industrial Microbiology & Biote… (2010)

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    Article

    Optimization of humanized IgGs in glycoengineered Pichia pastoris

    As the fastest growing class of therapeutic proteins, monoclonal antibodies (mAbs) represent a major potential drug class1. Human antibodies are glycosylated in their native state and all clinically approved mAbs...

    Huijuan Li, Natarajan Sethuraman, Terrance A Stadheim, Dongxing Zha… in Nature Biotechnology (2006)