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  1. No Access

    Article

    The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

    GDF15 has potent anti-obesity effects, but its receptor was previously unknown. GFRAL has now been identified as the receptor for GDF15, and it mediates the effects of GDF15 via central actions in the hindbrain.

    Paul J Emmerson, Feng Wang, Yong Du, Qian Liu, Richard T Pickard… in Nature Medicine (2017)

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    Article

    Transcriptional and post-transcriptional targeting for enhanced transient gene expression in CHO cells

    To develop a simple approach to increase titers of transient gene expression in CHO cells without relying on host cell line engineering as recent reports suggest that for PEI-mediated transfections, under opti...

    Yashas Rajendra, Maria D. Hougland, Matthew G. Schmitt… in Biotechnology Letters (2015)

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    Article

    High-throughput screening and selection of yeast cell lines expressing monoclonal antibodies

    The methylotrophic yeast Pichia pastoris has recently been engineered to express therapeutic glycoproteins with uniform human N-glycans at high titers. In contrast to the current art where producing therapeutic p...

    Gavin C. Barnard, Angela R. Kull… in Journal of Industrial Microbiology & Biote… (2010)