15 Result(s)

Article

Three-dimensional surface motion capture of multiple freely moving pigs using MAMMAL

Understandings of the three-dimensional social behaviors of freely moving large-size mammals are valuable for both agriculture and life science, yet challenging due to occlusions in close interactions. Althoug...

Liang An, Jilong Ren, Tao Yu, Tang Hai, Yichang Jia, Yebin Liu in Nature Communications (2023)

Article

Generation and characterization of stable pig pregastrulation epiblast stem cell lines

Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model development and livestock breeding. Despite ongoing attempts since the 1990s, ...

Minglei Zhi, **ying Zhang, Qianzi Tang, Dawei Yu, Shuai Gao, Dengfeng Gao… in Cell Research (2022)

Article

Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver

Mice with humanized livers are important models to study drug toxicology testing, development of hepatitis virus treatments, and hepatocyte transplantation therapy. However, the huge difference between mouse a...

Jilong Ren, Dawei Yu, **g Wang, Kai Xu, Yanan Xu, Renren Sun… in Cell & Bioscience (2022)

Article

Establishment of a humanized swine model for COVID-19

Xuguang Du, Zihang Guo, Wenhui Fan, Tang Hai, Fei Gao, Pan Li, Yumin Qin… in Cell Discovery (2021)

Article

Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs

Blastocyst complementation by pluripotent stem cell (PSC) injection is believed to be the most promising method to generate xenogeneic organs. However, ethical issues prevent the study of human chimeras in the...

Rui Fu, Dawei Yu, Jilong Ren, Chongyang Li, **g Wang, Guihai Feng… in Protein & Cell (2020)

Article

A novel porcine model reproduces human oculocutaneous albinism type II

Ying Zhang, Qianlong Hong, Chunwei Cao, Lizhu Yang, Yongshun Li, Tang Hai… in Cell Discovery (2019)

Article

One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system

Pig shows multiple superior characteristics in anatomy, physiology, and genome that have made this species to be more suitable models for human diseases, especially for neurodegenerative diseases, because they...

**anlong Wang, Chunwei Cao, Jiaojiao Huang, **g Yao, Tang Hai… in Scientific Reports (2016)

Article

Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs

Genetic engineering in livestock was greatly enhanced by the emergence of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9), which can be programmed with a single-gu...

**anlong Wang, **wei Zhou, Chunwei Cao, Jiaojiao Huang, Tang Hai… in Scientific Reports (2015)

Article

Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs

Pigs are ideal organ donors for xenotransplantation and an excellent model for studying human diseases, such as neurodegenerative disease. Transcription activator-like effector nucleases (TALENs) are used wide...

**g Yao, Jiaojiao Huang, Tang Hai, **anlong Wang, Guosong Qin… in Scientific Reports (2014)

Article

Efficient generation of mouse ESCs-like pig induced pluripotent stem cells

Qi Gu, Jie Hao, Tang Hai, Jianyu Wang, Yundan Jia, Qingran Kong… in Protein & Cell (2014)

Article

Epigenetic reprogramming, gene expression and in vitro development of porcine SCNT embryos are significantly improved by a histone deacetylase inhibitor—m-carboxycinnamic acid bishydroxamide (CBHA)

Insufficient epigenetic reprogramming of donor nuclei is believed to be one of the most important causes of low development efficiency of mammalian somatic cell nuclear transfer (SCNT). Previous studies have s...

Yuran Song, Tang Hai, Ying Wang, Runfa Guo, Wei Li, Liu Wang, Qi Zhou in Protein & Cell (2014)

Article

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

Tang Hai, Fei Teng, Runfa Guo, Wei Li, Qi Zhou in Cell Research (2014)

Article

Successful generation of cloned mice using nuclear transfer from induced pluripotent stem cells

Shuya Zhou, Chenhui Ding, **aoyang Zhao, Eryao Wang, **angpeng Dai… in Cell Research (2010)

Article

Efficient and rapid generation of induced pluripotent stem cells using an alternative culture medium

**ao-yang Zhao, Wei Li, Zhuo Lv, Lei Liu, Man Tong, Tang Hai, Jie Hao… in Cell Research (2010)

Article

Establishment of customized mouse stem cell lines by sequential nuclear transfer

Therapeutic cloning, whereby embryonic stem cells (ESCs) are derived from nuclear transfer (NT) embryos, may play a major role in the new era of regenerative medicine. In this study we established forty nuclea...

Chunli Zhao, Ruqiang Yao, Jie Hao, Chenhui Ding, Yong Fan, **angpeng Dai… in Cell Research (2007)