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Article
Definitive chemoradiotherapy induces T-cell-inflamed tumor microenvironment in unresectable locally advanced esophageal squamous cell carcinoma
Chemoradiotherapy (CRT) modulates the tumor immune microenvironment of multiple cancer types, including esophageal cancer, which potentially induces both immunogenicity and immunosuppression by upregulating th...
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Article
Open AccessCorrection: Palliative radiotherapy for tumor bleeding in patients with unresectable pancreatic cancer: a single-center retrospective study
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Article
Open AccessPalliative radiotherapy for tumor bleeding in patients with unresectable pancreatic cancer: a single-center retrospective study
Patients with unresectable pancreatic cancer (PC) sometimes experience gastrointestinal bleeding (GIB) due to tumor invasion of the gastrointestinal tract (tumor bleeding); no standard treatment has been estab...
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Article
Prognostic impact of EGFR/ALK alterations in leptomeningeal metastasis from lung adenocarcinoma treated with whole-brain radiotherapy
The prognosis and prognostic factors of patients receiving whole-brain radiotherapy (WBRT) for leptomeningeal metastasis (LM) from lung adenocarcinoma have not been established. Particularly, the impact of EGFR m...
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Article
Complete response to definitive chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma
Although definitive chemoradiotherapy (CRT) is the standard therapy for patients with unresectable locally advanced esophageal squamous cell carcinoma (ESCC), poor survival has been reported. Although the comp...
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Article
Open AccessTrajectories of cardiac troponin in the decades before cardiovascular death: a longitudinal cohort study
High-sensitivity cardiac troponin testing is a promising tool for cardiovascular risk prediction, but whether serial testing can dynamically predict risk is uncertain. We evaluated the trajectory of cardiac tr...
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Article
Open AccessGeneration of a Novel In Vitro Model to Study Endothelial Dysfunction from Atherothrombotic Specimens
Endothelial dysfunction is central to the pathogenesis of acute coronary syndrome. The study of diseased endothelium is very challenging due to inherent difficulties in isolating endothelial cells from the cor...
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Article
Open AccessCardiac biomarkers of prognostic importance in chronic obstructive pulmonary disease
Ischemic heart disease is common in COPD and associated with worse prognosis. This study aimed to investigate the presence and prognostic impact of biomarkers of myocardial injury and ischemia among individual...
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Article
Open AccessThe role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis
VEGF-A activity is tightly regulated by ligand and receptor availability. Here we investigate the physiological function of heterodimers between VEGF receptor-1 (VEGFR-1; Flt-1) and VEGFR-2 (KDR; Flk-1) (VEGFR1−2
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Article
Open AccessAutocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis
The negative feedback system is an important physiological regulatory mechanism controlling angiogenesis. Soluble vascular endothelial growth factor (VEGF) receptor-1 (sFlt-1), acts as a potent endogenous solu...
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Article
A case of normoreninemic aldosterone-producing adenoma associated with chronic renal failure
The diagnosis of aldosterone-producing adenoma (APA) is challenging for endocrinologists, as APA does not always present with the typical constellation of clinical and laboratory features, such as hypertension...
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Expression of Cell Cycle Regulators in Endometrial Adenocarcinoma
Abnormal expressions of cell cycle regulators, such as cyclin-dependent kinases (cdk), cyclins, and cyclin kinase inhibitors, are supposed to play an important role in the tumorigenesis and progression of carc...
