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Article
Open AccessA novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain
Heat shock proteins (HSPs) are present throughout the brain. They function as molecular chaperones, meaning they help with the folding and unfolding of large protein complexes. These chaperones are vital in th...
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Article
Open AccessNoradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus
The neuropathological changes of early Alzheimer’s disease (AD) include neurodegenerative loss of noradrenaline neurons in the locus coeruleus with decreasing noradrenaline availability in their projection are...
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Article
Correction: Evaluation of x-ray effective focal spot size dependency on x-ray exposure settings using edge response analysis
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Article
Evaluation of x-ray effective focal spot size dependency on x-ray exposure settings using edge response analysis
The effective focal spot size of x-ray tubes is one of the major factors that substantially affect the resultant x-ray images, and it is known to be dependent on the x-ray exposure setting used. This study aim...
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Article
Open AccessModulation of AMPK/ TET2/ 5-hmC axis in response to metabolic alterations as a novel pathway for obesity-related colorectal cancer development
Obesity is a major risk factor for colorectal cancer (CRC). Sustained hyperglycemia destabilizes tumor suppressor ten-eleven translocation (TET) 2, which is a substrate of AMPK, thereby dysregulating 5-hydroxy...
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Article
Atypical jejunal follicular lymphoma with severe stricture
The typical macroscopic appearance of gastrointestinal follicular lymphoma (FL) are multiple white granules or small white polyps, called multiple lymphomatous polyposis type, and subsequent mass lesions with ...
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Article
Open AccessNovel genomic alteration in superficial esophageal squamous cell neoplasms in non-smoker non-drinker females
Alcohol consumption and smoking pose a significant risk for esophageal squamous cell neoplasia (ESCN) development in males; however, ESCN is often diagnosed in non-drinking and non-smoking females. The mechani...
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Article
Open AccessDevelopment of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment
To develop antitumor drugs capable of targeting energy metabolism in the tumor microenvironment, we produced a series of potent new biguanide derivatives via structural modification of the arylbiguanide scaffo...
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Article
Does the increased motion probing gradient directional diffusion tensor imaging of lumbar nerves using multi-band SENSE improve the visualization and accuracy of FA values?
Diffusion tensor imaging (DTI) is useful to evaluate lumbar nerves visually and quantitatively. Multi-band sensitivity encoding (MB-SENSE) is a technique to reduce the scan time. This study aimed to investigat...
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Article
Open AccessLowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout
Heat shock protein 47 (HSP47) is an endoplasmic reticulum (ER)-resident molecular chaperone that specifically recognizes triple helical portions of procollagens. The chaperone function of HSP47 is indispensabl...
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Article
Effects of 2-(2-Chlorophenyl)ethylbiguanide on ERAD Component Expression in HT-29 Cells Under a Serum- and Glucose-Deprived Condition
We recently characterized the cytotoxic action of a novel phenformin derivative, 2-(2-chlorophenyl)ethylbiguanide (2-Cl-Phen), on HT-29 cells under a serum- and glucose-deprived condition and found that 2-Cl-P...
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Article
Elucidating the rapid action of 2-(2-chlorophenyl)ethylbiguanide on HT-29 cells under a serum- and glucose-deprived condition
We recently demonstrated the cytotoxic action of a novel phenformin derivative, 2-(2-chlorophenyl)ethylbiguanide (2-Cl-Phen), on HT-29 cells under a serum- and glucose-deprived condition. In that study, we sho...
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Chapter and Conference Paper
Process Analysis During Edge Preparation for Steel Plate Between Expert and Non-expert
As joining by welding is a particularly important processing method for melting and integrating multiple components. That is because poor welding is directly linked to fatal vulnerability in the product struct...
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Article
Elucidation of a novel phenformin derivative on glucose-deprived stress responses in HT-29 cells
Recently, we developed a variety of phenformin derivatives as selective antitumor agents. Based on previous findings, this study evaluated a promising compound, 2-(2-chlorophenyl)ethylbiguanide (2-Cl-Phen), on...
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Article
Solving Sparse Instances of Max SAT via Width Reduction and Greedy Restriction
We present a moderately exponential time and polynomial space algorithm for sparse instances of Max SAT. Our algorithms run in time of the form ...
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Article
Open AccessCharacteristics of dilatational infrasonic pulses accompanying low-frequency earthquakes at Miyakejima Volcano, Japan
Since the caldera-forming eruption of Miyakejima Volcano in 2000, low-frequency (LF) earthquakes have occurred frequently beneath the caldera. Some of these LF earthquakes are accompanied by emergent infrasoni...
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Chapter and Conference Paper
Solving Sparse Instances of Max SAT via Width Reduction and Greedy Restriction
We present a moderately exponential time polynomial space algorithm for sparse instances of Max SAT. Our algorithms run in time of the form O(2(1 − μ(c))n ) for instances with n variables and cn
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Article
Influence of climate fluctuation on clay formation in the Baikal drainage basin
Sedimentary cores BDP 96 and 98 and VER 96-2 St. 3 from Academician Ridge in Lake Baikal were investigated to investigate the effect of climatic fluctuations on rock weathering and clay formation in the Baikal...
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Article
Involvement of phosphatidylcholine hydrolysis by phospholipase C in prostaglandin F2Α-induced 1,2-diacylglycerol formation in osteoblast-like MC3T3-E1 cells
We previously demonstrated that a prostaglandin F2Α (PGF2Α)-induced, sustained increase in 1,2-diacylglycerol (DAG) production was important for proliferation in osteoblast-like MC3T3-E1 cells. The 1,2-DAG for...
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Article
Analysis of peculiar volcanic earthquakes at Satsuma-Iojima volcano
Fukuoka District Meteorological Observatory has continued seismic observations at Satsuma-Iojima volcano since September 1997. Of the daily number of seismic events at the volcano, which sometimes exceeded 100...
