-
Article
Maternal Ezetimibe Concentrations Measured in Breast Milk and Its Use in Breastfeeding Infant Exposure Predictions
Lactating mothers taking ezetimibe, an antihyperlipidemic agent, may be hesitant to breastfeed despite the known benefit of breastfeeding to both mother and infant. Currently, no data exist on the presence or ...
-
Article
Open AccessHSP47 levels determine the degree of body adiposity
Adiposity varies among individuals with the influence of diverse physiological, pathological, environmental, hormonal, and genetic factors, but a unified molecular basis remains elusive. Here, we identify HSP4...
-
Article
Cannabidiol Exposure Through Maternal Marijuana Use: Predictions in Breastfed Infants
Knowledge about exposure to cannabidiol (CBD) in breastfed infants can provide an improved understanding of potential risk. The aim was to predict CBD exposure in breastfed infants from mothers taking CBD and ...
-
Article
On-demand drug quantification: an increasing need in pediatric patients
-
Article
Open AccessMicrowaves reduce water refractive index
Microwaves, long used as a convenient household appliance, have been increasingly used in industrial processes such as organic synthesis and oil processing. It has been proposed that microwaves can enhance the...
-
Chapter
Pediatric Considerations when Prescribing Cannabis
In children (except for adolescents), intentional cannabis exposures are mainly seen in the context of medical use of cannabis for chronic diseases including epilepsy, cancer, pain control and other debilitati...
-
Article
Cognitive and behavioral risk factors for low quality of life in survivors of childhood acute lymphoblastic leukemia
With high survival rates for pediatric acute lymphoblastic leukemia (ALL), long-term quality of life is a prominent consideration in treatment. We concurrently evaluated cognition, behavior, and quality of lif...
-
Article
Correction to: Incorporating Breastfeeding-Related Variability with Physiologically Based Pharmacokinetic Modeling to Predict Infant Exposure to Maternal Medication Through Breast Milk: a Workflow Applied to Lamotrigine
A Correction to this paper has been published: https://doi.org/10.1208/s12248-021-00615-8
-
Article
Using Brexanolone for Postpartum Depression Must Account for Lactation
On March 19, 2019, Brexanolone (Zulresso ™) was released as the first-ever FDA-approved medication specifically for the treatment of postpartum depression by Sage Therapeutics, Inc. Unfortunately, its use in b...
-
Article
Correction to: Incorporating Breastfeeding-Related Variability with Physiologically Based Pharmacokinetic Modeling to Predict Infant Exposure to Maternal Medication Through Breast Milk: a Workflow Applied to Lamotrigine
A Correction to this paper has been published: https://doi.org/10.1208/s12248-021-00614-9
-
Article
Incorporating Breastfeeding-Related Variability with Physiologically Based Pharmacokinetic Modeling to Predict Infant Exposure to Maternal Medication Through Breast Milk: a Workflow Applied to Lamotrigine
Current methods to assess risk in infants exposed to maternal medication through breast milk do not specifically account for infants most vulnerable to high drug exposure. A workflow applied to lamotrigine inc...
-
Chapter and Conference Paper
Development of Expansive Agent Model in a Multi-scale Thermodynamic Framework Based on Hydration and Microstructure Formation
This study aims to develop an analytical tool to predict the expansion of Hauyne and free-lime based expansive additives in RC structures. Hydration of species was based on the multi-component heat of hydratio...
-
Article
CYP2C9, VKORC1, and CYP4F2 polymorphisms and pediatric warfarin maintenance dose: a systematic review and meta-analysis
Studies on the effect of cytochrome P450 2C9 (CYP2C9), vitamin K epoxide reductase complex subunit 1 (VKORC1), and cytochrome P450 4F2 (CYP4F2) polymorphisms on warfarin maintenance dose in children are conflicti...
-
Article
Open AccessSpectral cues are necessary to encode azimuthal auditory space in the mouse superior colliculus
Sound localization plays a critical role in animal survival. Three cues can be used to compute sound direction: interaural timing differences (ITDs), interaural level differences (ILDs) and the direction-depen...
-
Article
A critical review of the reproductive safety of Leflunomide
Leflunomide, an inhibitor of pyrimidine synthesis, is used for the treatment of rheumatic diseases, which are prevalent in women of childbearing age. Due to the very long half-life of the active metabolite, it...
-
Article
Open AccessLowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout
Heat shock protein 47 (HSP47) is an endoplasmic reticulum (ER)-resident molecular chaperone that specifically recognizes triple helical portions of procollagens. The chaperone function of HSP47 is indispensabl...
-
Article
Open AccessRole of days postdelivery on breast milk production: a secondary analysis from the EMPOWER trial
With an increasing demand for mother’s own milk to be viewed as a primary source of nutritional support in the care of very small and preterm infants, mothers of preterm infants may be at risk of expressing su...
-
Article
Substance Use in Pregnancy Among Vulnerable Women Seeking Addiction and Parenting Support
Substance use during pregnancy is associated with obstetrical and fetal complications. Though use of some substances is discontinued during pregnancy, use of others persists. Our goal was to characterize subst...
-
Article
Predicting Escitalopram Exposure to Breastfeeding Infants: Integrating Analytical and In Silico Techniques
Escitalopram is used for post-partum depression; however, there are limited pharmacokinetic data of escitalopram in milk and plasma of infants breastfed by women taking the drug.
-
Article
Open AccessPregnancy gestation at delivery and breast milk production: a secondary analysis from the EMPOWER trial
Preterm birth alters the normal sequence of lactogenesis. Lactogenesis I may not yet have started when mothers of very preterm infants (≤ 29 weeks gestation) have given birth. Preterm infants are too small or ...
