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within Takayuki Obita Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. Article

    Open Access

    Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation

    Brain inflammation generally accompanies and accelerates neurodegeneration. Here we report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses extrinsic tau 3R/4R proteins by direct ...

    Meihua **, Hiroki Shiwaku, Hikari Tanaka, Takayuki Obita… in Nature Communications (2021)

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  2. Article

    Open Access

    Transient α-helices in the disordered RPEL motifs of the serum response factor coactivator MKL1

    The megakaryoblastic leukemia 1 (MKL1) protein functions as a transcriptional coactivator of the serum response factor. MKL1 has three RPEL motifs (RPEL1, RPEL2 and RPEL3) in its N-terminal region. MKL1 binds ...

    Mineyuki Mizuguchi, Takahiro Fuju, Takayuki Obita, Mitsuru Ishikawa… in Scientific Reports (2014)

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  3. No Access

    Article

    Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5–15kD

    A loss-of-function of polyglutamine tract-binding protein 1 (PQBP1) induced by frameshift mutations is believed to cause X-linked mental retardation. However, the mechanism by which structural changes in PQBP1...

    Mineyuki Mizuguchi, Takayuki Obita, Tomohito Serita, Rieko Kojima… in Nature Communications (2014)

  4. No Access

    Article

    Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

    In yeast, two ESCRT-III-related subunits, Vps2 and Did2 bind to Vps4. The crystal structure of Vps2 bound to Vp4 s is presented, elucidating the basis for selective recognition of the ESCRT-III complex.

    Takayuki Obita, Suraj Saksena, Sara Ghazi-Tabatabai, David J. Gill, Olga Perisic… in Nature (2007)