-
Article
PNPO–PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity
Oxygen is critical for all metazoan organisms on the earth and impacts various biological processes in physiological and pathological conditions. While oxygen-sensing systems inducing acute hypoxic responses, ...
-
Article
Feasible living donor liver transplantation for patients on chronic hemodialysis: a multicenter study in East Asian countries
End-stage liver and kidney disease is an indication for simultaneous liver and kidney transplantation. However, in countries where deceased donor transplantation is not well established, living donor liver tra...
-
Article
Open AccessNon-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1 functions solely by stimulating DNA methylation maintena...
-
Article
Open AccessPulsed muon facility of J-PARC MUSE
J-PARC Muon Facility: MUSE (Muon Science Establishment) is responsible for the inter-university user program and the operation, maintenance, and construction of the muon beamlines, namely D-line, S-line, U-lin...
-
Article
Open AccessEffects of combination therapy of antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation: a systematic review and meta-analysis
Disseminated intravascular coagulation (DIC) syndrome is a highly lethal condition characterized by the complication of multiple organ damage. Although the effects of combined antithrombin (AT) and recombinant...
-
Article
Open AccessPhysiological and immunological barriers in the lung
The lungs serve as the primary organ for respiration, facilitating the vital exchange of gases with the bloodstream. Given their perpetual exposure to external particulates and pathogens, they possess intricat...
-
Article
Open AccessTranscription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature
Direct reprogramming, inducing the conversion of one type of somatic cell into another by the forced expression of defined transcription factors, is a technology with anticipated medical applications. However,...
-
Article
Open AccessBrazilian green propolis prevent Alzheimer’s disease-like cognitive impairment induced by amyloid beta in mice
The increasing incidence of cognitive impairment has become a health problem in the aging society. Owing to its antioxidant and anti-inflammatory properties, Brazilian green propolis—derived from Baccharis dracun...
-
Article
Open AccessDNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle
Each tissue has a dominant set of functional proteins required to mediate tissue-specific functions. Epigenetic modifications, transcription, and translational efficiency control tissue-dominant protein produc...
-
Article
Invasive features of superficial oesophageal squamous cell carcinoma—analysis of risk factors for lymph node metastasis
There are currently no studies that have examined the clinicopathological factors in detail, including the histological images of the invasive front, and the risk of lymph node metastasis (LNM) in superficial ...
-
Article
Open AccessDamage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury
Upon cellular injury, damage-associated molecular patterns (DAMPs) are released into the extracellular space and evoke proinflammatory and prothrombotic responses in animal models of sterile inflammation. Howe...
-
Article
Open AccessA highly efficient scheme for library preparation from single-stranded DNA
Although methods for sequencing library preparation from double-stranded DNA are well established, those from single-stranded DNA (ssDNA) have not been well studied. Further, the existing methods have limitati...
-
Article
Open AccessAnaplastic lymphoma kinase overexpression enhances aggressive phenotypic characteristics of endometrial carcinoma
Although anaplastic lymphoma kinase (ALK) is overexpressed in several primary solid tumor types, its role in endometrial carcinoma (Em Ca) remains unclear.
-
Article
An adult case of refractory autoimmune neutropenia after liver transplantation
Autoimmune neutropenia (AIN) is an exceptionally rare condition that occurs after liver transplantation. Here, we report an adult case of refractory AIN 3.5 years after liver transplantation. A 59-year-old man...
-
Article
A genome-wide screen reveals new regulators of the 2-cell-like cell state
In mammals, only the zygote and blastomeres of the early embryo are totipotent. This totipotency is mirrored in vitro by mouse ‘2-cell-like cells’ (2CLCs), which appear at low frequency in cultures of embryoni...
-
Article
Open AccessAuthor Correction: Astronomical forcing shaped the timing of early Pleistocene glacial cycles
-
Article
Open AccessExosomes induce neurogenesis of pluripotent P19 cells
Exosomes play a role in tissue/organ development and differentiation. Retinoic acid induces differentiation of P19 cells (UD-P19) to P19 neurons (P19N) that behave like cortical neurons and express characteri...
-
Article
Open AccessAstronomical forcing shaped the timing of early Pleistocene glacial cycles
Glacial cycles during the early Pleistocene are characterised by a dominant 41,000-year periodicity and amplitudes smaller than those of glacial cycles with ~100,000-year periodicity during the late Pleistocen...
-
Article
Impact of liver volumetric regeneration on survival outcomes in patients with hepatocellular carcinoma after major hepatectomy
Prognostic value of liver volumetric regeneration (LVR) in patients with hepatocellular carcinoma (HCC) who undergo major hepatectomy remains unknown. The aim of this study was to investigate the impact of LVR...
-
Article
A case of type 2 autoimmune pancreatitis with spontaneous remission
A 70-year-old man with epigastric pain was referred to our hospital. Computed tomography and magnetic resonance imaging showed the diffusely enlarged pancreas compared to his normal pancreas 6 months prior to ...
