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Article
Open AccessNucleobindin 2 inhibits senescence in gastric carcinoma
Here, we focused on the role of Nucleobindin 2 (NUCB2), a multifunctional protein, in gastric carcinoma (GC) progression. NUCB2 expression was investigated in 150 GC cases (20 non-invasive (pT1) and 130 invasi...
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Article
Open AccessAnaplastic lymphoma kinase overexpression enhances aggressive phenotypic characteristics of endometrial carcinoma
Although anaplastic lymphoma kinase (ALK) is overexpressed in several primary solid tumor types, its role in endometrial carcinoma (Em Ca) remains unclear.
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Article
Open AccessPTEN overexpression and nuclear β-catenin stabilization promote morular differentiation through induction of epithelial–mesenchymal transition and cancer stem cell-like properties in endometrial carcinoma
Although a lack of functional PTEN contributes to tumorigenesis in a wide spectrum of human malignancies, little is known about the functional role of its overexpression in the tumors. The current study focuse...
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Article
Open AccessA functional role of S100A4/non-muscle myosin IIA axis for pro-tumorigenic vascular functions in glioblastoma
Glioblastoma (GBM) is the most aggressive form of brain tumor and has vascular-rich features. The S100A4/non-muscle myosin IIA (NMIIA) axis contributes to aggressive phenotypes in a variety of human malignanci...
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Article
Open AccessFunctional interaction between S100A1 and MDM2 may modulate p53 signaling in normal and malignant endometrial cells
S100A1 expression is deregulated in a variety of human malignancies, but its role in normal and malignant endometrial cells is unclear.
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Article
Open AccessNodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions
Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involve...
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Article
Open AccessA functional role of LEFTY during progesterone therapy for endometrial carcinoma
The left-right determination factor (LEFTY) is a novel member of the TGF-β/Smad2 pathway and belongs to the premenstrual/menstrual repertoire in human endometrium, but little is known about its functional role...
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Article
Open AccessCooperation of Sox4 with β-catenin/p300 complex in transcriptional regulation of the Slug gene during divergent sarcomatous differentiation in uterine carcinosarcoma
Uterine carcinosarcoma (UCS) represents a true example of cancer associated with epithelial-mesenchymal transition (EMT), which exhibits cancer stem cell (CSC)-like traits. Both Sox and β-catenin signal transd...
