10 Result(s)

Article

Radio-sensitizing effect of MEK inhibition in glioblastoma in vitro and in vivo

Glioblastoma (GBM) is an incurable cancer type. New therapeutic options are investigated, including targeting the mitogen-activated protein kinase (MAPK) pathway using MEK inhibitors as radio-sensitizers. In t...

M. Houweling, U. K. Abdul, C. Brahm… in Journal of Cancer Research and Clinical On… (2023)

Article

Suicidal gene therapy in an NF-κB-controlled tumor environment as monitored by a secreted blood reporter

The nuclear factor-κB (NF-κB) is known to be activated in many cancer types including lung, ovarian, astrocytomas, melanoma, prostate as well as glioblastoma, and has been shown to correlate with disease progr...

C E Badr, J M Niers, D Morse, J A Koelen, P Vandertop, D Noske, T Wurdinger… in Gene Therapy (2011)

Chapter and Conference Paper

In-vivo red fluorescent protein tomography

We report on a novel mutli-spectral tomographic method that allows the 3D visualization of fluorescence protein activity in small animals. The method makes use of a novel spectral inversion scheme that integra...

N. C. Deliolanis, T. Wurdinger, L. Pike… in World Congress on Medical Physics and Biom… (2009)

Article

Molecular therapy in the microRNA era

MicroRNAs (miRNAs) consist of a growing class of non-coding RNAs (ncRNAs) that negatively regulate the expression of genes involved in development, differentiation, proliferation, apoptosis and other important...

T Wurdinger, F F Costa in The Pharmacogenomics Journal (2007)

Article

Antibody-mediated targeting of viral vectors to the Fc receptor expressed on acute myeloid leukemia cells

T Würdinger, M H Verheije, L M van der Aa, B J Bosch, C A M de Haan… in Leukemia (2006)

Article

Targeting non-human coronaviruses to human cancer cells using a bispecific single-chain antibody

To explore the potential of using non-human coronaviruses for cancer therapy, we first established their ability to kill human tumor cells. We found that the feline infectious peritonitis virus (FIPV) and a fe...

T Würdinger, M H Verheije, M Raaben, B J Bosch, C A M de Haan… in Gene Therapy (2005)

Article

Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors

Conditionally replicative adenoviruses (CRAds) are potentially useful agents for anticancer virotherapy approaches. However, lack of coxsackievirus and adenovirus receptor (CAR) expression on many primary tumo...

V W van Beusechem, D C J Mastenbroek, P B van den Doel, M L M Lamfers… in Gene Therapy (2003)

Chapter and Conference Paper

Implanted Pump Systems for Treatment of Spasticity

In about one third of patients with violent spasticity due to spinal trauma, multiple sclerosis, and diffuse brain injury adequate control with oral antispastic medication cannot be achieved and successful reh...

Prof. Dr. J. Zierski, H. Müller, D. Dralle… in Proceedings of the 8^th European Congress o… (1988)