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Open AccessMitochondrial DNAs provide insight into trypanosome phylogeny and molecular evolution
Trypanosomes are single-celled eukaryotic parasites characterised by the unique biology of their mitochondrial DNA. African livestock trypanosomes impose a major burden on agriculture across sub-Saharan Africa...
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Article
Open AccessTransporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites
The acquisition of genes by horizontal transfer can impart entirely new biological functions and provide an important route to major evolutionary innovation. Here we have used ancient gene reconstruction and f...
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Article
Familial hyperaldosteronism type III
Primary aldosteronism is the most common form of endocrine hypertension. This disorder comprises both sporadic and familial forms. Four familial forms of primary aldosteronism (FH-I to FH-IV) have been describ...
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Article
ARMC5 mutation analysis in patients with primary aldosteronism and bilateral adrenal lesions
Idiopathic hyperaldosteronism (IHA) due to bilateral adrenal hyperplasia is the most common subtype of primary aldosteronism (PA). The pathogenesis of IHA is still unknown, but the bilateral disease suggests a...
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Article
Changing cell behaviours during beetle embryogenesis correlates with slowing of segmentation
Segmented animals are found in major clades as phylogenetically distant as vertebrates and arthropods. Typically, segments form sequentially in what has been thought to be a regular process, relying on a segme...
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Article
Outcome of ranibizumab treatment in neovascular age related macula degeneration in eyes with baseline visual acuity better than 6/12
The beneficial effect of intravitreal ranibizumab in the treatment of neovascular age-related macula degeneration (nAMD) is well known. Outcome data for eyes presenting with visual acuity better than 6/12 is l...
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Article
12.16 Primary Aldosteronism and Endothelial Progenitor Cell Bioavailability
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10.21 Liver X Receptor Agonists Induce Endothelial Dysfunction
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Article
A late presentation of ocular quinine toxicity managed with a combination of vasodilatory treatments
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Cost of Care in Critical Illness
Intensive care units (ICUs) are an expensive [1–4] and growing [4,5] part of health care in developed nations. Greater consumer expectations, ageing populations [6, 7], demand for sophisticated technologies [8], ...
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Article
Coexistence of different phenotypes in a family with glucocorticoid-remediable aldosteronism
In glucocorticoid-remediable aldosteronism (GRA), there is a large interfamily variation of phenotype. We report three subjects with GRA in a single family (parents, two brothers and two sisters), of whom only...
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Article
Earlier flowering between 1962 and 2002 in agricultural varieties of white clover
Date of first flowering was recorded for 40 years in the same agricultural varieties of white clover ( Trifolium repens L.). Standard procedures, experimental conditions and germplasm allowed the unmediated effec...
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Article
Quality characteristics of backcross hybrids between Trifolium repens and Trifolium ambiguum
Two generations of novel backcross hybrids between white clover (Trifolium repens L.) and the related species Trifolium ambiguum,with white clover as the recurrent parent, were analysed for forage quality charact...
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Article
Distalless expression in crustaceans and the patterning of branched limbs
In Drosophila, Distalless (Dll) is critical in establishing the proximal/distal axis of the leg. Lack of proper Dll expression causes distal limb structures to be truncated or lost. Dll expression was examined t...
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Article
Limb development in a primitive crustacean, Triops longicaudatus: subdivision of the early limb bud gives rise to multibranched limbs
Recent advances in developmental genetics of Drosophila have uncovered some of the key molecules involved in the positioning and outgrowth of the leg primordia. Although expression patterns of these molecules ha...
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Article
Segmentation in the crustacean Artemia: engrailed staining studied with an antibody raised against the Artemia protein
We have studied the process of post-embryonic segmentation in the anostracan crustacean Artemia franciscana using a specific antibody raised against the engrailed protein of this organism. Three cephalic segments...
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Article
Coexistence and the productivity of white clover-perennial ryegrass mixtures
Yield comparisons between five white cloverperennial ryegrass mixtures, whose individual components had previously coexisted, and a corresponding set of ten mixtures based on components that had not coexisted ...
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Article
Effects of coexistence on the performance of white clover-perennial ryegrass mixtures
Yields from five white clover/perennial ryegrass mixtures, each based on coexisting components, were compared with those produced by ten mixtures whose constituents had no previous history of coexistence. The ...
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Article
Computer technology in mental health care: “Toys” or tools?
An argument is made that applications of on-line computer technology which are truly relevant to decision making constitute the new “tools of the trade” in mental health care delivery.
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Erratum to: A simple user-oriented program for computer constructed narratives
