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  1. No Access

    Article

    Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine

    A simple and practical 10-step synthesis is reported for previously unknown diastereomers of C‑methylated spermine (Spm) analogue, 1,12-diamino-3,10-dimethyl-4,9-diazadodecane (3,10-Me2Spm), starting from commerc...

    M. A. Khomutov, M. T. Hyvönen, A. I. Salikhov… in Russian Journal of Bioorganic Chemistry (2020)

  2. No Access

    Article

    Hydroxylamine derivatives for regulation of spermine and spermidine metabolism

    The biogenic polyamines spermine, spermidine, and their precursor putrescine are present in micro-to-millimolar concentrations in all cell types and are vitally important for their normal growth. High intracel...

    M. A. Khomutov, J. Weisell, M. Hyvönen, T. A. Keinänen… in Biochemistry (Moscow) (2013)

  3. No Access

    Article

    Novel metabolically stable and functionally active mimetic of spermidine

    Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1-acetyltransferase nor spermine synthase, but was...

    M. A. Khomutov, M. T. Hyvönen, A. R. Simonian… in Russian Journal of Bioorganic Chemistry (2011)

  4. No Access

    Article

    Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis

    The markers of oxidative stress and inflammation were studied in acute pancreatitis in transgenic rats exhibiting activated polyamine catabolism. In addition, the effect of bismethylspermine (Me2Spm) pretreatment...

    M. Merentie, A. Uimari, M. Pietilä, R. Sinervirta, T. A. Keinänen… in Amino Acids (2007)