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  1. Article

    Open Access

    Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting

    Colorectal cancer-specific biomarkers have been used as molecular targets for fluorescent intra-operative imaging, targeted PET/MRI, and selective cytotoxic drug delivery yet the selection of biomarkers used i...

    J P Tiernan, S L Perry, E T Verghese, N P West, S Yeluri… in British Journal of Cancer (2013)

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  2. Article

    Open Access

    Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

    Cancer cells are highly dependent on glycolysis. Our aim was to determine if switching metabolism from glycolysis towards mitochondrial respiration would reduce growth preferentially in colorectal cancer cells...

    B M Madhok, S Yeluri, S L Perry, T A Hughes, D G Jayne in British Journal of Cancer (2010)

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  3. Article

    Open Access

    Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity

    Increased eukaryotic translation initiation factor 4E (eIF4E) expression occurs in many cancers, and makes fundamental contributions to carcinogenesis by stimulating the expression of cancer-related genes at p...

    L J Coleman, M B Peter, T J Teall, R A Brannan, A M Hanby… in British Journal of Cancer (2009)

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  4. No Access

    Article

    Degradation of Aromatic Hydrocarbons by Sphingomonas paucimobilis Strain EPA505

    To determine the substrate range capability of Sphingomonas paucimobilis strain EPA505, a number of aromatic compounds were tested as potential growth substrates. Strain EPA505 grew on phenanthrene, naphthalen...

    S. P. Story, E. L. Kline, T. A. Hughes… in Archives of Environmental Contamination an… (2004)

  5. No Access

    Article

    Toluene Mineralization and Growth Potential of Pseudomonas putida PaW164 Under Toluene-Limiting Conditions

    T. G. H. Lim, K.-D. Gan, T. A. Hughes… in Archives of Environmental Contamination an… (2001)

  6. No Access

    Chapter

    Transcription factories and chromosome structure

    Condensation is the hallmark of mitosis. Why, then, does the chromatin fibre not condense into the most compact form, a sphere? Why are chromatids cylindrical, and not spherical? What are the basic principles ...

    A. Pombo, J. McManus, T. A. Hughes, F. J. Iborra, D. A. Jackson… in Chromosomes Today (1997)

  7. No Access

    Article

    Oxidation behavior of three commercial ODS alloys at 1200°C

    The isothermal-oxidation behavior of three oxide-dispersion-strengthened (ODS) alloys, viz., MA 956, ODM 751, and PM 2000, has been examined in air at 1200°C for exposure times up to 4800 hr. During exposure a...

    M. Turker, T. A. Hughes in Oxidation of Metals (1995)

  8. No Access

    Article

    Erwinia pel gene homology survey in selected bacteria

    A 2.1 kb Bam H1 DNA fragment encoding a pectate lyase (PL) enzyme was isolated from an Erwinia carotovora subsp. atroseptica (Eca) cosmid library. The fragment was labeled with 32P-CTP and hybridized to total DNA...

    G. J. Fennington, T. A. Hughes in Plant and Soil (1990)

  9. No Access

    Article

    Study of theRhizobium japonicum-soybean symbiosis

    Capsular polysaccharides were isolated fromRhizobium japonicum (61A76NS) and conjugated to a fluorescent dye to determine if the specificity in theRhizobium japonicum-soybean symbiosis is expressed by a component...

    T. A. Hughes, G. H. Elkan in Plant and Soil (1981)