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  1. Article

    Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy

    The anti-tumour effects associated with oncolytic virus therapy are mediated significantly through immune-mediated mechanisms, which depend both on the type of virus and the route of delivery. Here, we show th...

    E Ilett, T Kottke, J Thompson, K Rajani, S Zaidi, L Evgin, M Coffey… in Gene Therapy (2017)

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    Article

    Lead identification and optimization of diaminopyrimidines as histamine H4 receptor ligands

    The human histamine H4 receptor (hH4R) is a promising new target in the therapy of inflammatory or immune system diseases.

    K. Sander, T. Kottke, E. Proschak, Y. Tanrikulu, E. H. Schneider… in Inflammation Research (2010)

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    Article

    Search for histamine H4 receptor ligands in the group of 4-methylpiperazino amide derivatives

    T. Karcz, J. Handzlik, D. Łażewska, T. Kottke, R. Seifert… in Inflammation Research (2010)

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    Article

    Search for novel, high affinity histamine H3 receptor ligands with fluorescent properties

    K. J. Kuder, T. Kottke, H. Stark, X. Ligneau, J.-C. Camelin… in Inflammation Research (2010)

  5. Article

    Single-cycle viral gene expression, rather than progressive replication and oncolysis, is required for VSV therapy of B16 melanoma

    A fully intact immune system would be expected to hinder the efficacy of oncolytic virotherapy by inhibiting viral replication. Simultaneously, however, it may also enhance antitumor therapy through initiation...

    F Galivo, R M Diaz, P Wongthida, J Thompson, T Kottke, G Barber, A Melcher… in Gene Therapy (2010)

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    Article

    Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunity

    Reovirus is a naturally occurring oncolytic virus currently in early clinical trials. However, the rapid induction of neutralizing antibodies represents a major obstacle to successful systemic delivery. This s...

    E J Ilett, R J Prestwich, T Kottke, F Errington, J M Thompson… in Gene Therapy (2009)

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    Article

    Loading of oncolytic vesicular stomatitis virus onto antigen-specific T cells enhances the efficacy of adoptive T-cell therapy of tumors

    Although adoptive T-cell therapy has shown clinical success, efficacy is limited by low levels of T-cell trafficking to, and survival in, the immunosuppressive environment of an established tumor. Oncolytic vi...

    J Qiao, H Wang, T Kottke, R M Diaz, C Willmon, A Hudacek, J Thompson… in Gene Therapy (2008)

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    Article

    Synergy of adoptive T-cell therapy and intratumoral suicide gene therapy is mediated by host NK cells

    In situ tumor cell killing by the herpes simplex virus thymidine kinase (HSVtk) gene can effectively prime antitumor T-cell responses, at least in part through local induction of a pro-inflammatory environment. T...

    L Sanchez-Perez, M Gough, J Qiao, U Thanarajasingam, T Kottke, A Ahmed… in Gene Therapy (2007)

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    Article

    VSV-G pseudotyped, MuLV-based, semi-replication-competent retrovirus for cancer treatment

    Low levels of gene delivery in vivo using replication-defective retroviral vectors have severely limited their application for clinical protocols. To overcome this problem, we describe here a semi-replication-com...

    J Qiao, J Moreno, L Sanchez-Perez, T Kottke, J Thompson, M Caruso, R M Diaz… in Gene Therapy (2006)

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    Article

    The perforin-dependent immunological synapse allows T-cell activation-dependent tumor targeting by MLV vector particles

    We have reported that retroviral particles adhered to the surface of antigen-specific T cells can be carried to metastases following adoptive transfer in vivo, a process we have called viral hitch hiking. Followi...

    T Kottke, J Qiao, R M Diaz, A Ahmed, B Vroman, J Thompson, L Sanchez-Perez… in Gene Therapy (2006)

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    Article

    Intratumoral expression of a fusogenic membrane glycoprotein enhances the efficacy of replicating adenovirus therapy

    We describe here a novel strategy to enhance the in vivo efficacy of replicating adenovirus therapy, using coinjection of plasmid DNA encoding a fusogenic viral glycoprotein. The combination of fusogenic membrane...

    A Ahmed, D Jevremovic, K Suzuki, T Kottke, J Thompson, S Emery… in Gene Therapy (2003)

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    Article

    Combustion synthesis and subsequent Explosive Densification of Titanium Carbide Ceramics

    Explosive densification following combustion synthesis of titanium and graphite powder mixtures has been used to fabricate bulk compacts (100-mm diameter × 20-mm thick) of TiC ceramics. A model rocket ignitor ...

    H. A. Grebe, A. Advani, N. N. Thadhani, T. Kottke in Metallurgical Transactions A (1992)

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    Article

    Dynamic modelling of material and process parameter effects on self-propagating high-temperature synthesis of titanium carbide ceramics

    A dynamic, finite-difference model evaluation of titanium carbide (TiC) ceramic processing by self-propagation high-temperature synthesis (SHS) has revealed that material and process parameters have a signific...

    A. H. Advani, H. N. Thadhani, H. A. Grebe, R. Heaps… in Journal of Materials Science (1992)