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Article
Open AccessMulti-wavelength fluorescence imaging with a da Vinci Firefly—a technical look behind the scenes
The field of fluorescence-guided surgery builds on colored fluorescent tracers that have become available for different clinical applications. Combined use of complementary fluorescent emissions can allow visu...
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Article
Anatomical localization of radiocolloid tracer deposition affects outcome of sentinel node procedures in prostate cancer
Diagnostic imaging modalities have moderate sensitivity for the identification of lymph node (LN) metastases in prostate cancer (PCa) patients. Map** the lymphatic drainage from the prostate can help to iden...
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Article
A prediction model relating the extent of intraoperative fascia preservation to erectile dysfunction after nerve-sparing robot-assisted radical prostatectomy
Robot-assisted radical prostatectomy (RARP) is performed in patients with prostate cancer. Unfortunately, 10–46% of patients may still suffer from limited erectile function (EF) after RARP. This study aimed to...
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Article
Open AccessThe best of both worlds: a hybrid approach for optimal pre- and intraoperative identification of sentinel lymph nodes
Hybrid image-guided surgery technologies such as combined radio- and fluorescence-guidance are increasingly gaining interest, but their added value still needs to be proven. In order to evaluate if and how flu...
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Article
11 Is de locatie van intraprostatische tracertoediening van invloed op het lymfedrainagepatroon? Analyse met behulp van een hybride tracer
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Article
Open AccessPaclitaxel in self-micro emulsifying formulations: oral bioavailability study in mice
The anticancer drug paclitaxel is formulated for i.v. administration in a mixture of Cremophor EL and ethanol. Its oral bioavailability is very low due to the action of P-glycoprotein in the gut wall and CYP45...
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Article
4 Combineren van preoperatieve schildwachtklierlokalisatie met fluorescentiegeleide robotgeassisteerde schildwachtklierbiopsie in prostaatkankerpatiënten
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Article
Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice
Trabectedin is a novel anticancer drug active against soft tissue sarcomas. Trabectedin is a substrate for P-glycoprotein (P-gp), which is encoded by mdr1a/1b in rodents. Plasma and tissue distribution, and excre...
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Article
Open AccessP-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo
ABC transporter proteins may protect haematopoietic progenitor cells from chemotherapy-induced toxicity. By using an in vitro colony-forming assay, we found that bone marrow of Mdr1ab, Mrp1, Mdr1ab/Mrp1 knockout ...
