-
Article
Open AccessImplementing a patient decision aid, a process evaluation of a large-scale pre- and post-implementation trial
Patient decision aids (PtDAs) have been reported to have a positive influence on patients making a health care decision in trials. Nevertheless, post-trial implementation is poor. The aim of this study is to e...
-
Article
The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs
The large-scale genetic profiling of tumours can identify potentially actionable molecular variants for which approved anticancer drugs are available1–3. However, when patients with such variants are treated with...
-
Article
Open AccessStudy protocols of three parallel phase 1 trials combining radical radiotherapy with the PARP inhibitor olaparib
Poly (ADP-ribose) Polymerase (PARP) inhibitors are promising novel radiosensitisers. Pre-clinical models have demonstrated potent and tumour-specific radiosensitisation by PARP inhibitors. Olaparib is a PARP i...
-
Article
Open AccessThe best of both worlds: a hybrid approach for optimal pre- and intraoperative identification of sentinel lymph nodes
Hybrid image-guided surgery technologies such as combined radio- and fluorescence-guidance are increasingly gaining interest, but their added value still needs to be proven. In order to evaluate if and how flu...
-
Article
Phase I study of combined indomethacin and platinum-based chemotherapy to reduce platinum-induced fatty acids
Chemotherapy-resistance remains a major obstacle to effective anti-cancer treatment. We previously showed that platinum analogs cause the release of two fatty acids. These platinum-induced fatty acids (PIFAs) ...
-
Article
Open AccessShort-term outcome after cystectomy: comparison of early oral feeding in an enhanced recovery protocol and feeding using Bengmark nasojejunal tube
Cystectomy for bladder cancer is associated with a high risk of postoperative complications. Standardized perioperative protocols, such as enhanced recovery after surgery (ERAS) protocols, aim to improve posto...
-
Article
An Antiestrogenic Activity Score for tamoxifen and its metabolites is associated with breast cancer outcome
Endoxifen concentrations have been associated with breast cancer recurrence in tamoxifen-treated patients. However, tamoxifen itself and other metabolites also show antiestrogenic anti-tumor activity. Therefor...
-
Article
Quantification of patient-reported outcome measures of radiation-induced skin reactions for use in clinical trial design
Skin toxicity is a common effect from radiotherapy, although difficult to predict on an individual basis, and there is little evidence-based management. This study aimed to quantify inter-patient variation in ...
-
Article
The performance of model-based versus rule-based phase I clinical trials in oncology
Phase I studies with anticancer drugs are used to evaluate safety and tolerability and to choose a recommended phase II dose (RP2D). Traditionally, phase I trial designs are rule-based, but for several years t...
-
Article
Very low local recurrence rates after breast-conserving therapy: analysis of 8485 patients treated over a 28-year period
The purpose of this study was to study the impact of changes in clinical practice on outcome in patients treated with breast-conserving therapy (BCT) over a period of 28 years. Patients with early invasive bre...
-
Article
The prognostic value of the neoadjuvant response index in triple-negative breast cancer: validation and comparison with pathological complete response as outcome measure
The Neoadjuvant response index (NRI) has been proposed as a simple measure of downstaging by neoadjuvant treatment in breast cancer. It was previously found to predict recurrence-free survival (RFS) in triple-...
-
Article
Open AccessNeoadjuvant chemotherapy adaptation and serial MRI response monitoring in ER-positive HER2-negative breast cancer
Changing the neoadjuvant chemotherapy regimen in insufficiently responding breast cancer is not a standard policy. We analysed a series of patients with ‘luminal’-type breast cancer in whom the second half of ...
-
Article
Differences in histopathological evaluation of standard lymph node dissections result in differences in nodal count but not in survival
To analyse whether the reported differences in nodal yield at pelvic lymph node dissection (PLND) for bladder cancer, between two hospitals, are reflected in the survival rates.
-
Article
8 De waarde van echogeleide cytologische punctie in de follow-up van de liesklieren bij peniscarcinoom
-
Article
19 Inductiechemotherapie en chirurgie bij klierpositief blaascarcinoom
-
Article
Association of primary tumour FDG uptake with clinical, histopathological and molecular characteristics in breast cancer patients scheduled for neoadjuvant chemotherapy
The aim of this study was to evaluate the association of primary tumour 18F-fluorodeoxyglucose (FDG) uptake with clinical, histopathological and molecular characteristics of breast cancer patients scheduled for n...
-
Article
Langetermijnoverleving bij peniscarcinoom; ervaring met 1000 opeenvolgende patiënten
