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10 Result(s)
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Syuzanna R. Harutyunyan
English
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Article
Open AccessA catalytically active oscillator made from small organic molecules
Oscillatory systems regulate many biological processes, including key cellular functions such as metabolism and cell division, as well as larger-scale processes such as circadian rhythm and heartbeat1–4. Abiotic ...
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Article
Open AccessCatalytic enantioselective addition of organometallics to unprotected carboxylic acids
Conjugate addition of organometallics to carbonyl based Michael acceptors is a widely used method that allows the building of new carbon-carbon (C-C) bonds and the introduction of chirality in a single step. H...
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Article
Open AccessHighly enantioselective catalytic synthesis of chiral pyridines
General methods to prepare chiral pyridine derivatives are greatly sought after due to their significance in medicinal chemistry. Here, we report highly enantioselective catalytic transformations of poorly rea...
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Article
Cu-catalyzed enantioselective allylic alkylation with organolithium reagents
Cu-catalyzed asymmetric allylic alkylation (AAA) is used in the synthesis of pharmaceuticals and natural products. This protocol uses organolithium reagents in the Cu-catalyzed AAA of allylic substrates with T...
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Article
Open AccessCatalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines
α-Chiral amines are of significant importance in medicinal chemistry, asymmetric synthesis and material science, but methods for their efficient synthesis are scarce. In particular, the synthesis of α-chiral a...
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Book
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Chapter
1,2- Versus 1,4-Asymmetric Addition of Grignard Reagents to Carbonyl Compounds
The first copper(I)-catalysed conjugate addition of Grignard reagents to α,β-unsaturated carbonyl compounds was reported in 1941. Impressive developments have been made since then, with catalytic asymmetric ad...
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Article
Electrically driven directional motion of a four-wheeled molecule on a metal surface
Any future artificial transporters and robots operating at the nanoscale are likely to require molecules capable of directional translational movement over a surface. Even the design of such molecules is a dau...
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Article
Catalytic asymmetric carbon–carbon bond formation via allylic alkylations with organolithium compounds
Carbon–carbon bond formation is the basis for the biogenesis of nature's essential molecules. Consequently, it lies at the heart of the chemical sciences. Chiral catalysts have been developed for asymmetric C–...
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Article
Reversing the direction in a light-driven rotary molecular motor
Biological rotary motors can alter their mechanical function by changing the direction of rotary motion. Achieving a similar reversal of direction of rotation in artificial molecular motors presents a fundamen...
